PSRC1 - proline and serine rich coiled-coil 1 Gene

Homo sapiens

Also known as DDA3; FP3214

Gene ID: 84722 | Gene type: protein coding

About PSRC1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,279,556-109,283,145 (from NCBI)

This gene has 12 transcripts (splice variants), 106 orthologues and 1 paralogue. Broad expression in brain (RPKM 9.0), testis (RPKM 4.6) and 23 other tissues.

Summary

This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]

PSRC1 Products(14)

mRNA	Protein	Name
NM_001005290.4	NP_001005290.1	proline/serine-rich coiled-coil protein 1 isoform b
NM_001032291.3	NP_001027462.1	proline/serine-rich coiled-coil protein 1 isoform a
NM_001350237.2	NP_001337166.1	proline/serine-rich coiled-coil protein 1 isoform d
NM_001350238.2	NP_001337167.1	proline/serine-rich coiled-coil protein 1 isoform d
NM_001350239.2	NP_001337168.1	proline/serine-rich coiled-coil protein 1 isoform d
NM_001350240.2	NP_001337169.1	proline/serine-rich coiled-coil protein 1 isoform d
NM_001350241.2	NP_001337170.1	proline/serine-rich coiled-coil protein 1 isoform d
NM_001350242.2	NP_001337171.1	proline/serine-rich coiled-coil protein 1 isoform d
NM_001363309.2	NP_001350238.1	proline/serine-rich coiled-coil protein 1 isoform c
NM_001394002.1	NP_001380931.1	proline/serine-rich coiled-coil protein 1 isoform a
NM_001394003.1	NP_001380932.1	proline/serine-rich coiled-coil protein 1 isoform b
NM_001394004.1	NP_001380933.1	proline/serine-rich coiled-coil protein 1 isoform b
NM_001394005.1	NP_001380934.1	proline/serine-rich coiled-coil protein 1 isoform c
NM_032636.8	NP_116025.1	proline/serine-rich coiled-coil protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18411309	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitotic metaphase chromosome alignment	IDA IDA: Inferred from direct assay	18411309	GOA
involved in regulation of mitotic spindle organization	IDA IDA: Inferred from direct assay	18411309	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	18411309	GOA
colocalizes with spindle microtubule	IDA IDA: Inferred from direct assay	18411309	GOA
colocalizes with spindle pole	IDA IDA: Inferred from direct assay	18411309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSRC1 Protein Structure

GTSE1_N

0
100
200
300
363 a.a.

Protein Preferred Names

Protein Names

proline/serine-rich coiled-coil protein 1

differential display and activated by p53

PSRC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSRC1	Q6PGN9	MAPRE3	Homo sapiens	Q9UPY8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pulmonary Embolism And Infarction

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11343	PSRC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PSRC1	VGNC	VGNC:33484
Felis catus	PSRC1	VGNC	VGNC:64418
Canis familiaris	PSRC1	VGNC	VGNC:45125
Rattus norvegicus	PSRC1	RGD	RGD:1585037
Macaca mulatta	PSRC1	VGNC	VGNC:76307
Mus musculus	PSRC1	MGD	MGI:1913099

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