UNC119B - unc-119 lipid binding chaperone B Gene

Homo sapiens

Also known as POC7B

Gene ID: 84747 | Gene type: protein coding

About UNC119B

This gene has 3 transcripts (splice variants), 267 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 22.0), ovary (RPKM 19.5) and 24 other tissues.

Summary

Enables lipid binding activity. Involved in cilium assembly and lipoprotein transport. Located in ciliary transition zone. [provided by Alliance of Genome Resources, Apr 2022]

UNC119B Products(1)

mRNA	Protein	Name
NM_001080533.3	NP_001074002.1	protein unc-119 homolog B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables lipid binding	IDA IDA: Inferred from direct assay	22085962	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22085962	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	22085962	GOA
involved in lipoprotein transport	IDA IDA: Inferred from direct assay	22085962	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in ciliary transition zone	IDA IDA: Inferred from direct assay	22085962	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UNC119B Protein Structure

GMP_PDE_delta

0
100
200
251 a.a.

Protein Preferred Names

Protein Names

protein unc-119 homolog B

POC7 centriolar protein homolog B

UNC119B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UNC119B	A6NIH7	NPHP3	Homo sapiens	Q7Z494	FPS	22960633

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Macular Degeneration, X-Linked Atrophic

X-Linked Atrophic Macular Degeneration	Macular Degeneration, X-Linked, Atrophic
MDXLA	Degeneration, Macular, X-Linked Atrophic

Joubert Syndrome 22

JBTS22

Joubert Syndrome, Type 22

Retinitis Pigmentosa 2

RP2	X-Linked Retinitis Pigmentosa 2
Xlrp2	Xlrp-2
Retinitis Pigmentosa-2	Retinitis Pigmentosa, Type 2

Nephronophthisis 2

NPHP2	Nph2
Nephronophthisis 2, Infantile	Infantile Nephronophthisis 2
Infantile Nephronophthisis	Nephronophthisis, Type 2

Nephronophthisis

Medullary Cystic Disease	Medullary Cystic Kidney
Nph	Nphp
Kidney Disease, Cystic, Medullary

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-164368	GLUT4 activator 2	Activator	/	Unkown
HY-RS15463	UNC119B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	UNC119B	VGNC	VGNC:66821
Rattus norvegicus	UNC119B	RGD	RGD:1309359
Mus musculus	UNC119B	MGD	MGI:2147162
Bos taurus	UNC119B	VGNC	VGNC:36663
Canis familiaris	UNC119B	VGNC	VGNC:48134

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