GPR65 - G protein-coupled receptor 65 Gene

Homo sapiens

Also known as TDAG8; hTDAG8

Gene ID: 8477 | Gene type: protein coding

About GPR65

Cytogenetic location: 14q31.3 Genomic coordinates (GRCh38): 14:88,005,135-88,014,811 (from NCBI)

This gene has 1 transcript (splice variant), 175 orthologues and 16 paralogues. Broad expression in appendix (RPKM 6.3), bone marrow (RPKM 5.3) and 18 other tissues.

Summary

Enables G protein-coupled receptor activity. Involved in several processes, including actin Cytoskeleton reorganization; activation of GTPase activity; and positive regulation of stress fiber assembly. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR65 Products(1)

mRNA	Protein	Name
NM_003608.4	NP_003599.2	psychosine receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	15618224	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15618224	GOA
involved in activation of GTPase activity	IDA IDA: Inferred from direct assay	15618224	GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15618224	GOA
involved in positive regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	15618224	GOA
involved in response to acidic pH	IDA IDA: Inferred from direct assay	15618224	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	15618224	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR65 Protein Structure

7tm_1

0
100
200
300
337 a.a.

Protein Preferred Names

Protein Names

psychosine receptor

T-cell death-associated gene 8 protein

Related Diseases

Diseases

Alias

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Aleutian Mink Disease

Aleutian Disease

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149164	BTB09089	Agonist	99.43%	Unkown
HY-162734	BRD5075	Inhibitor	98.08%	Unkown
HY-162735	BRD5080		/	Unkown
HY-RS05730	GPR65 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GPR65	VGNC	VGNC:73140
Bos taurus	GPR65	VGNC	VGNC:29596
Mus musculus	GPR65	MGD	MGI:108031
Rattus norvegicus	GPR65	RGD	RGD:1311832
Felis catus	GPR65	VGNC	VGNC:67437
Canis familiaris	GPR65	VGNC	VGNC:41442
Others	GPR65	NCBI

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