KMT5C - lysine methyltransferase 5C Gene

Homo sapiens

Also known as SUV420H2; Suv4-20h2

Gene ID: 84787 | Gene type: protein coding

About KMT5C

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,339,876-55,348,121 (from NCBI)

This gene has 12 transcripts (splice variants), 172 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 1.9), placenta (RPKM 1.5) and 25 other tissues.

Summary

SUV420H2 and the related Enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009]

KMT5C Products(1)

mRNA	Protein	Name
NM_032701.4	NP_116090.2	histone-lysine N-methyltransferase KMT5C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables S-adenosyl-L-methionine binding	IDA IDA: Inferred from direct assay	24049080	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	28114273	GOA
enables histone H4K20 methyltransferase activity	IDA IDA: Inferred from direct assay	24049080	GOA
enables histone H4K20 methyltransferase activity	IMP IMP: Inferred from mutant phenotype	28114273	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19486527	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA repair	IMP IMP: Inferred from mutant phenotype	28114273	GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	28114273	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in heterochromatin	IDA IDA: Inferred from direct assay	19486527	GOA
located in pericentric heterochromatin	IDA IDA: Inferred from direct assay	19486527	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KMT5C Protein Structure

SET

0
100
200
300
400
462 a.a.

Protein Preferred Names

Protein Names

histone-lysine N-methyltransferase KMT5C

[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B

KMT5C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KMT5C	Q86Y97	CBX3	Homo sapiens	Q13185	Pull Down	19486527
Intra	KMT5C	Q86Y97	CBX3	Homo sapiens	Q13185	TAP	24981860

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KMT5C Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77218	SUV420H2 Protein, Human (His)	Q86Y97-1 (G2-L280)	≥95%

Related Diseases

Diseases

Alias

Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1	HP1
Glycolic Aciduria	Alanine-Glyoxylate Aminotransferase Deficiency
Hepatic Agt Deficiency	Oxalosis I
Primary Hyperoxaluria, Type I	Serine:Pyruvate Aminotransferase Deficiency
Hyperoxaluria, Primary, Type 1	Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency
Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency	Serine Pyruvate Aminotransferase Deficiency
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Oxalosis 1
Hyperoxaluria Primary 1	Hyperoxaluria Primary Type I
Ph1	Primary Hyperoxaluria Type I
Oxalosis Type 1	2-Oxoglutarate Glyoxylate Carboligase Deficiency

Primary Hyperoxaluria

Hyperoxaluria	Hyperoxaluria, Primary
Oxalosis	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07408	KMT5C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KMT5C	VGNC	VGNC:42495
Mus musculus	KMT5C	MGD	MGI:2385262
Bos taurus	KMT5C	VGNC	VGNC:30695
Felis catus	KMT5C	VGNC	VGNC:63164
Rattus norvegicus	KMT5C	RGD	RGD:1305226
Others	KMT5C	NCBI

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