2. Gene
  3. CBX3 - chromobox 3 Gene

CBX3 - chromobox 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HECH; HP1-GAMMA; HP1Hs-gamma

Gene ID: 11335 | Gene type: protein coding

About CBX3

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:26,201,443-26,213,607 (from NCBI)

This gene has 8 transcripts (splice variants), 183 orthologues and 8 paralogues. Ubiquitous expression in lymph node (RPKM 47.3), testis (RPKM 43.1) and 25 other tissues.

Summary

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]

CBX3 Products(3)

mRNA Protein Name
NM_001410866.1 NP_001397795.1 chromobox protein homolog 3 isoform b
NM_007276.5 NP_009207.2 chromobox protein homolog 3 isoform a
NM_016587.4 NP_057671.2 chromobox protein homolog 3 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
19486527 GOA
enables histone methyltransferase binding IPI
IPI: Inferred from physical interaction
19486527 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
19486527 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8663349 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
8663349 GOA
enables transcription coregulator binding IPI
IPI: Inferred from physical interaction
29795351 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
27248496 GOA
involved in heterochromatin formation IDA
IDA: Inferred from direct assay
17540172 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9636147 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
9636147 GOA
Cellular Component GO Annotation Evidence Reference Source
part of RNA polymerase II transcription regulator complex IDA
IDA: Inferred from direct assay
29795351 GOA
located in chromatin IDA
IDA: Inferred from direct assay
11101528 GOA
part of chromatin lock complex IPI
IPI: Inferred from physical interaction
17540172 GOA
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
10504293 GOA
located in euchromatin IDA
IDA: Inferred from direct assay
11124534 GOA
located in heterochromatin IDA
IDA: Inferred from direct assay
11124534 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17540172 GOA
located in site of DNA damage IMP
IMP: Inferred from mutant phenotype
27248496 GOA
located in spindle IDA
IDA: Inferred from direct assay
11101528 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBX3 Protein Structure

Chromo

Chromo: Chromo (CHRromatin Organisation MOdifier) domain (30 - 78)

Chromo_shadow

Chromo_shadow: Chromo shadow domain (119 - 176)

  • 0
  • 100
  • 183 a.a.
Protein Preferred Names Protein Names

chromobox protein homolog 3

HP1 gamma homolog

CBX3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CBX3 Q13185 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
CBX3 Q13185 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
CBX3 Q13185 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
32296183
Intra
CBX3 Q13185 LBR Homo sapiens Q14739
Y2H
8663349
Intra
CBX3 Q13185 ZNF280D Homo sapiens Q6N043-2
Y2H Prey Pooling
32296183
Intra
CBX3 Q13185 ZNF280D Homo sapiens Q6N043-2
Validated Y2H
32296183
Intra
CBX3 Q13185 ZNF280D Homo sapiens Q6N043-2
Y2H Array
32296183
Intra
CBX3 Q13185 ADNP Homo sapiens Q9H2P0
Anti Bait CoIP
36950384
Intra
CBX3 Q13185 ADNP Homo sapiens Q9H2P0
Anti Tag CoIP
33961781
Intra
CBX3 Q13185 ADNP Homo sapiens Q9H2P0
TAP
24981860
Intra
CBX3 Q13185 ADNP Homo sapiens Q9H2P0
TAP
27705803
Intra
CBX3 Q13185 ADNP Homo sapiens Q9H2P0
TAP
21888893
Intra
CBX3 Q13185 GDF15 Homo sapiens Q99988
Validated Y2H
32296183
Intra
CBX3 Q13185 GDF15 Homo sapiens Q99988
Y2H Array
32296183
Intra
CBX3 Q13185 GDF15 Homo sapiens Q99988
Y2H Prey Pooling
32296183
Intra
CBX3 Q13185 LAP3 Homo sapiens P28838
Y2H Array
32296183
Intra
CBX3 Q13185 LAP3 Homo sapiens P28838
Y2H Prey Pooling
32296183
Intra
CBX3 Q13185 MGA Homo sapiens Q8IWI9
TAP
24981860
Intra
CBX3 Q13185 MGA Homo sapiens Q8IWI9
TAP
27705803
Intra
CBX3 Q13185 MGA Homo sapiens Q8IWI9
Anti Tag CoIP
33961781
Intra
CBX3 Q13185 ADNP2 Homo sapiens Q6IQ32
TAP
27705803
Intra
CBX3 Q13185 ADNP2 Homo sapiens Q6IQ32
Anti Tag CoIP
33961781
Intra
CBX3 Q13185 ADNP2 Homo sapiens Q6IQ32
Y2H Prey Pooling
32296183
Intra
CBX3 Q13185 ADNP2 Homo sapiens Q6IQ32
Validated Y2H
32296183
Intra
CBX3 Q13185 ADNP2 Homo sapiens Q6IQ32
Y2H Array
32296183
Intra
CBX3 Q13185 SUV39H1 Homo sapiens O43463
TAP
27705803
Intra
CBX3 Q13185 MRPL12 Homo sapiens P52815
Y2H Prey Pooling
32296183
Intra
CBX3 Q13185 MRPL12 Homo sapiens P52815
Y2H Array
32296183
Intra
CBX3 Q13185 LRIF1 Homo sapiens Q5T3J3
TAP
27705803
Intra
CBX3 Q13185 LRIF1 Homo sapiens Q5T3J3
TAP
21888893
Intra
CBX3 Q13185 LRIF1 Homo sapiens Q5T3J3
Anti Tag CoIP
33961781
Intra
CBX3 Q13185 LRIF1 Homo sapiens Q5T3J3
TAP
24981860
Intra
CBX3 Q13185 LRIF1 Homo sapiens Q5T3J3
Validated Y2H
32296183
Intra
CBX3 Q13185 PRR14 Homo sapiens Q9BWN1
TAP
27705803
Intra
CBX3 Q13185 PRR14 Homo sapiens Q9BWN1
Y2H Prey Pooling
32296183
Intra
CBX3 Q13185 PRR14 Homo sapiens Q9BWN1
Validated Y2H
32296183
Intra
CBX3 Q13185 PRR14 Homo sapiens Q9BWN1
Y2H Array
32296183
Intra
CBX3 Q13185 TRIM28 Homo sapiens Q13263
Y2H Pooling
20936779
Intra
CBX3 Q13185 TRIM28 Homo sapiens Q13263
TAP
27705803
Intra
CBX3 Q13185 TRIM28 Homo sapiens Q13263
TAP
21888893
Intra
CBX3 Q13185 KMT5C Homo sapiens Q86Y97
Pull Down
19486527
Intra
CBX3 Q13185 H3C1 Homo sapiens P68431
Protein Array
20871592
Intra
CBX3 Q13185 H3C1 Homo sapiens P68431
TAP
24981860
Intra
CBX3 Q13185 H3C1 Homo sapiens P68431
Pull Down
16415788
Intra
CBX3 Q13185 ZNF280C Homo sapiens Q8ND82
Validated Y2H
32296183
Intra
CBX3 Q13185 ZNF280C Homo sapiens Q8ND82
TAP
27705803
Cross
CBX3 Q13185 legAS4 Legionella pneumophila subsp. pneumophila Q5ZUS4
Y2H
23797873
Cross
CBX3 Q13185 legAS4 Legionella pneumophila subsp. pneumophila Q5ZUS4
Anti Bait CoIP
23797873
Intra
CBX3 Q13185 RAD54L2 Homo sapiens Q9Y4B4
Y2H Prey Pooling
32296183
Intra
CBX3 Q13185 RAD54L2 Homo sapiens Q9Y4B4
Validated Y2H
32296183
Intra
CBX3 Q13185 RAD54L2 Homo sapiens Q9Y4B4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

CBX3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80707 HP1 gamma Antibody (YA733) WB, IHC-F, IHC-P, ICC/IF, IP Mouse, Human, Monkey, Hamster, Rat

Related Diseases

Diseases Alias
Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson Gilford Progeria Syndrome

Hutchinson-Gilford Disease

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome
Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1

HP1

Glycolic Aciduria

Alanine-Glyoxylate Aminotransferase Deficiency

Hepatic Agt Deficiency

Oxalosis I

Primary Hyperoxaluria, Type I

Serine:Pyruvate Aminotransferase Deficiency

Hyperoxaluria, Primary, Type 1

Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency

Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency

Serine Pyruvate Aminotransferase Deficiency

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Oxalosis 1

Hyperoxaluria Primary 1

Hyperoxaluria Primary Type I

Ph1

Primary Hyperoxaluria Type I

Oxalosis Type 1

2-Oxoglutarate Glyoxylate Carboligase Deficiency
Primary Hyperoxaluria

Hyperoxaluria

Hyperoxaluria, Primary

Oxalosis

Primary Oxalosis

Congenital Oxaluria

D-Glycerate Dehydrogenase Deficiency

Glyceric Aciduria

Glycolic Aciduria

Hepatic Agt Deficiency

Oxaluria, Primary

Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

Primary Oxaluria

Hyperoxaluria Primary

Primary Hyperoxaluria Type 2

Primary Hyperoxaluria, Type I
Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis
Facioscapulohumeral Muscular Dystrophy 1

Facioscapulohumeral Muscular Dystrophy

Fshd

Landouzy-Dejerine Muscular Dystrophy

Muscular Dystrophy, Facioscapulohumeral

FSHD1

Fshd1a

Muscular Dystrophy, Facioscapulohumeral, Type 1a

Facioscapulohumeral Muscular Dystrophy Type 1a

Fsh Muscular Dystrophy

Facioscapulohumeral Muscular Dystrophy 1a

Facioscapulohumeral Atrophy

Facioscapulohumeral Myopathy

Muscular Dystrophy, Facioscapulohumeral, Type 1

Facioscapulohumeral Muscular Dystrophy Type 1

Landouzy Dejerine Muscular Dystrophy

Muscular Dystrophy, Landouzy-Dejerine

Fshmd1a

Facio-Scapulo-Humeral Dystrophy

Facioscapulohumeral Type Progressive Muscular Dystrophy

Facioscapuloperoneal Muscular Dystrophy

Facioscapulohumeral Dystrophy

Fsh Dystrophy

Landouzy-Dejerine Dystrophy

Landouzy-Dejerine Myopathy

Fmd

Facioscapulohumeral Muscular Dystrophy-1a

Muscular Dystrophy Facioscapulohumeral

Dystrophy, Muscular, Facioscapulohumeral

Dystrophy, Muscular, Facioscapulohumeral, Type 1

Landouzy-Dejerine Disease

Landouzy-Déjerine Atrophy

Facioscapulohumeral Muscle Dystrophy

Fmd - [Facioscapulohumeral Muscular Dystrophy]

Fsh - [Facioscapulohumeral Muscular Dystrophy]

Fshd - [Facioscapulohumeral Muscular Dystrophy]

Landouzy-Déjerine Dystrophy Or Facioscapulohumeral Atrophy

Landouzy-Déjérine Muscular Dystrophy
Facioscapulohumeral Muscular Dystrophy 2, Digenic

Facioscapulohumeral Muscular Dystrophy 2

FSHD2

Fshd1b

Facioscapulohumeral Muscular Dystrophy 1b

Fshd2, Digenic

Muscular Dystrophy, Facioscapulohumeral, Type 2

Muscular Dystrophy, Facioscapulohumeral, Type 1b

Fascioscapulohumeral Muscular Dystrophy 2, Digenic

Facioscapulohumeral Muscular Dystrophy Type 2

Digenic Facioscapulohumeral Muscular Dystrophy

Digenic Fshd2

Facioscapulohumeral Muscular Dystrophy Type 1b

Dystrophy, Muscular, Facioscapulohumeral, Type 2
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome

Immunodeficiency Syndrome, Variable

Ciid

Centromeric Instability, Immunodeficiency Syndrome

Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16

Icf
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02010 CBX3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CBX3 VGNC VGNC:50017
Rattus norvegicus CBX3 RGD RGD:1549705
Mus musculus CBX3 MGD MGI:108515