PLCD4 - phospholipase C delta 4 Gene

Homo sapiens

Gene ID: 84812 | Gene type: protein coding

About PLCD4

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,607,899-218,637,175 (from NCBI)

This gene has 15 transcripts (splice variants), 294 orthologues and 14 paralogues. Broad expression in esophagus (RPKM 2.6), testis (RPKM 2.2) and 23 other tissues.

Summary

This gene encodes a member of the delta class of Phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for Cancer. [provided by RefSeq, Jan 2011]

PLCD4 Products(1)

mRNA	Protein	Name
NM_032726.4	NP_116115.1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-protein alpha-subunit binding	IPI IPI: Inferred from physical interaction	30194280	GOA
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	30194280	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in small GTPase-mediated signal transduction	IDA IDA: Inferred from direct assay	30194280	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLCD4 Protein Structure

EF-hand_10

EF-hand_like

PI-PLC-X

PI-PLC-Y

0
200
400
600
762 a.a.

Protein Preferred Names

Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

PLC delta4

PLCD4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PLCD4	Q9BRC7	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	PLCD4	Q9BRC7	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	PLCD4	Q9BRC7	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	PLCD4	Q9BRC7	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Colorectal Cancer, Hereditary Nonpolyposis, Type 4

HNPCC4	Hereditary Nonpolyposis Colorectal Cancer Type 4
Hereditary Non-Polyposis Colorectal Cancer 4	Cancer, Colorectal, Nonpolyposis, Hereditary, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10658	PLCD4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PLCD4	MGD	MGI:107469
Bos taurus	PLCD4	VGNC	VGNC:32986
Canis familiaris	PLCD4	VGNC	VGNC:44649
Felis catus	PLCD4	VGNC	VGNC:68898
Rattus norvegicus	PLCD4	RGD	RGD:621025
Macaca mulatta	PLCD4	VGNC	VGNC:76167
Others	PLCD4	NCBI

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