CBR4 - carbonyl reductase 4 Gene

Homo sapiens

Also known as SDR45C1

Gene ID: 84869 | Gene type: protein coding

About CBR4

Cytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:168,894,486-169,010,255 (from NCBI)

This gene has 7 transcripts (splice variants) and 194 orthologues. Ubiquitous expression in lung (RPKM 23.4), fat (RPKM 17.8) and 25 other tissues.

Summary

Enables several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NADPH binding activity; and NADPH dehydrogenase (quinone) activity. Involved in fatty acid biosynthetic process; glycoside metabolic process; and protein tetramerization. Located in mitochondrial matrix. Part of oxidoreductase complex. [provided by Alliance of Genome Resources, Apr 2022]

CBR4 Products(1)

mRNA	Protein	Name
NM_032783.5	NP_116172.2	3-oxoacyl-[acyl-carrier-protein] reductase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	IDA IDA: Inferred from direct assay	19571038	GOA
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	IMP IMP: Inferred from mutant phenotype	25203508	GOA
enables NAD(P)H dehydrogenase (quinone) activity	IDA IDA: Inferred from direct assay	20837989	GOA
enables NADPH binding	IDA IDA: Inferred from direct assay	19000905	GOA
enables NADPH dehydrogenase (quinone) activity	IDA IDA: Inferred from direct assay	19000905	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19571038	GOA
enables quinone binding	IDA IDA: Inferred from direct assay	19000905	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in daunorubicin metabolic process	IMP IMP: Inferred from mutant phenotype	20837989	GOA
involved in doxorubicin metabolic process	IMP IMP: Inferred from mutant phenotype	20837989	GOA
involved in fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	25203508	GOA
involved in protein heterotetramerization	IDA IDA: Inferred from direct assay	25203508	GOA
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	19000905	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	19000905	GOA
part of oxidoreductase complex	IDA IDA: Inferred from direct assay	19571038	GOA
part of oxidoreductase complex	IMP IMP: Inferred from mutant phenotype	25203508	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBR4 Protein Structure

adh_short

0
100
200
237 a.a.

Protein Preferred Names

Protein Names

3-oxoacyl-[acyl-carrier-protein] reductase

3-ketoacyl-[acyl-carrier-protein] reductase beta subunit

Related Diseases

Diseases

Alias

Bile Acid Synthesis Defect, Congenital, 5

Congenital Bile Acid Synthesis Defect 5	CBAS5
Bile Acid Synthesis Defect, Congenital, Type 5

Horner'S Syndrome

Horner Syndrome	Bernard-Horner Syndrome
Oculosympathetic Palsy	Bernard Horner Syndrome
Cervical Sympathetic Paralysis	Von Passow Syndrome
Cervical Sympathetic Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02006	CBR4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CBR4	VGNC	VGNC:26815
Mus musculus	CBR4	MGD	MGI:2384567
Macaca mulatta	CBR4	VGNC	VGNC:70635
Canis familiaris	CBR4	VGNC	VGNC:38765
Rattus norvegicus	CBR4	RGD	RGD:727826
Felis catus	CBR4	VGNC	VGNC:60424

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