ZXDC - ZXD family zinc finger C Gene

Homo sapiens

Also known as ZXDL

Gene ID: 79364 | Gene type: protein coding

About ZXDC

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:126,437,601-126,475,891 (from NCBI)

This gene has 4 transcripts (splice variants), 306 orthologues and 14 paralogues. Ubiquitous expression in bone marrow (RPKM 13.7), spleen (RPKM 5.6) and 25 other tissues.

Summary

Enables C2H2 zinc finger domain binding activity; LRR domain binding activity; and transcription coactivator activity. Involved in positive regulation of transcription, DNA-templated. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZXDC Products(2)

mRNA	Protein	Name
NM_001040653.4	NP_001035743.1	zinc finger protein ZXDC isoform 2
NM_025112.5	NP_079388.3	zinc finger protein ZXDC isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables C2H2 zinc finger domain binding	IPI IPI: Inferred from physical interaction	17493635	GOA
enables LRR domain binding	IPI IPI: Inferred from physical interaction	16600381	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16600381	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	17493635	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17696781	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16600381	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZXDC Protein Structure

zf-C2H2_4

zf-C2H2

zf-H2C2_2

zf-C2H2

zf-C2H2_4

0
200
400
600
800
858 a.a.

Protein Preferred Names

Protein Names

zinc finger protein ZXDC

SERH2790

Related Diseases

Diseases

Alias

Microcephalic Osteodysplastic Primordial Dwarfism, Type Ii

Microcephalic Osteodysplastic Primordial Dwarfism Type Ii	Majewski Osteodysplastic Primordial Dwarfism Type Ii
MOPD2	Mopd Ii
Osteodysplastic Primordial Dwarfism Type Ii	Mopdii
Osteodysplastic Primordial Dwarfism Type 2	Osteodysplastic Primordial Dwarfism, Type Ii
Pcnt-Related Microcephalic Osteodysplastic Primordial Dwarfism	Microcephalic Osteodysplastic Primordial Dwarfism Type 2
Mopd 2	Microcephalic Osteodysplastic Primordial Dwarfism With Tooth Abnormalities
Mopd Type Ii	Microcephalic Osteodysplastic Primordial Dwarfism 2
Dwarfism, Primordial, Osteodysplastic, Microcephalic Type Ii

Moyamoya Disease 1

Moyamoya Disease	Spontaneous Occlusion Of The Circle Of Willis
Mymy	Progressive Intracranial Arterial Occlusion
Moyamoya Syndrome	MYMY1
Cerebrovascular Moyamoya Disease	Moya-Moya Disease
Progressive Intracranial Occlusive Arteropathy	Idiopathic Moyamoya Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16213	ZXDC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZXDC	VGNC	VGNC:82559
Bos taurus	ZXDC	VGNC	VGNC:37392
Canis familiaris	ZXDC	VGNC	VGNC:48867
Felis catus	ZXDC	VGNC	VGNC:67391
Rattus norvegicus	ZXDC	RGD	RGD:1561296
Mus musculus	ZXDC	MGD	MGI:1933108

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