FIBCD1 - fibrinogen C domain containing 1 Gene

Homo sapiens

Gene ID: 84929 | Gene type: protein coding

About FIBCD1

Cytogenetic location: 9q34.12 Genomic coordinates (GRCh38): 9:130,902,440-130,940,709 (from NCBI)

This gene has 7 transcripts (splice variants), 232 orthologues and 25 paralogues. Biased expression in testis (RPKM 2.4), adrenal (RPKM 1.6) and 6 other tissues.

Summary

FIBCD1 is a conserved type II transmembrane endocytic receptor that binds chitin and is located primarily in the intestinal brush border (Schlosser et al., 2009 [PubMed 19710473]).[supplied by OMIM, Apr 2010]

FIBCD1 Products(2)

mRNA	Protein	Name
NM_001145106.2	NP_001138578.1	fibrinogen C domain-containing protein 1
NM_032843.5	NP_116232.3	fibrinogen C domain-containing protein 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chitin binding	IDA IDA: Inferred from direct assay	19710473	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	19710473	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FIBCD1 Protein Structure

Fibrinogen_C

0
100
200
300
400
461 a.a.

Protein Preferred Names

Protein Names

fibrinogen C domain-containing protein 1

FIBCD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FIBCD1	Q8N539	MAL	Homo sapiens	P21145	Y2H Prey Pooling	25416956
Intra	FIBCD1	Q8N539	MAL	Homo sapiens	P21145	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Diamond-Blackfan Anemia 1

Aase Syndrome	DBA1
Erythrogenesis Imperfecta	Aase-Smith Syndrome Ii
Dba	Blackfan-Diamond Syndrome
Bds	Anemia, Congenital Hypoplastic, Of Blackfan And Diamond
Anemia, Congenital Erythroid Hypoplastic	Red Cell Aplasia, Pure, Hereditary
Aregenerative Anemia, Chronic Congenital	Rps19-Related Diamond-Blackfan Anemia
Chronic Congenital Aregenerative Anemia	Congenital Erythroid Hypoplastic Anemia
Congenital Hypoplastic Anemia Of Blackfan And Diamond	Pure Hereditary Red Cell Aplasia
Anemia, Diamond-Blackfan, Type 1	Anemia, Diamond-Blackfan
Aase Smith Syndrome 2	Familial Hypoplastic Anaemia With Malformations
Constitutional Pure Red Cell Aplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04940	FIBCD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FIBCD1	VGNC	VGNC:72579
Rattus norvegicus	FIBCD1	RGD	RGD:1309097
Bos taurus	FIBCD1	VGNC	VGNC:29005
Canis familiaris	FIBCD1	VGNC	VGNC:40877
Mus musculus	FIBCD1	MGD	MGI:2138953
Felis catus	FIBCD1	VGNC	VGNC:62269

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