PPFIBP2 - PPFIA binding protein 2 Gene

Homo sapiens

Also known as Cclp1

Gene ID: 8495 | Gene type: protein coding

About PPFIBP2

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:7,513,999-7,667,304 (from NCBI)

This gene has 29 transcripts (splice variants), 292 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 8.3), testis (RPKM 6.8) and 24 other tissues.

Summary

This gene encodes a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. The encoded protein is a beta liprin and plays a role in axon guidance and neuronal synapse development by recruiting LAR protein-tyrosine phosphatases to the plasma membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

PPFIBP2 Products(13)

mRNA	Protein	Name
NM_001256568.2	NP_001243497.2	liprin-beta-2 isoform 2
NM_001256569.2	NP_001243498.2	liprin-beta-2 isoform 3
NM_001351853.2	NP_001338782.2	liprin-beta-2 isoform 4
NM_001351854.2	NP_001338783.2	liprin-beta-2 isoform 5
NM_001351855.2	NP_001338784.2	liprin-beta-2 isoform 6
NM_001351856.2	NP_001338785.2	liprin-beta-2 isoform 7
NM_001351857.2	NP_001338786.2	liprin-beta-2 isoform 8
NM_001351858.2	NP_001338787.2	liprin-beta-2 isoform 9
NM_001351859.2	NP_001338788.2	liprin-beta-2 isoform 10
NM_001351860.2	NP_001338789.2	liprin-beta-2 isoform 11
NM_001351861.2	NP_001338790.2	liprin-beta-2 isoform 12
NM_001351862.2	NP_001338791.2	liprin-beta-2 isoform 1
NM_003621.5	NP_003612.3	liprin-beta-2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	21462929	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19447967	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPFIBP2 Protein Structure

Integrase_DNA

SAM_1

SAM_2

0
200
400
600
800
876 a.a.

Protein Preferred Names

Protein Names

liprin-beta-2

PTPRF interacting protein, binding protein 2 (liprin beta 2)

PPFIBP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPFIBP2	Q8ND30	HSF4	Homo sapiens	Q9ULV5-2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bile Duct Cancer

Bile Duct Carcinoma	Extrahepatic Bile Duct Carcinoma
Carcinoma Of Extrahepatic Bile Duct	Extrahepatic Bile Duct Cancer
Bile Duct Neoplasms	Bile Duct Tumor
Ca Extrahepatic Bile Ducts	Malignant Neoplasm Of The Extrahepatic Bile Duct
Bile Duct Extrahepatic Carcinoma	Malignant Tumor Of Extrahepatic Bile Duct

Bile Duct Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10944	PPFIBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPFIBP2	MGD	MGI:894649
Felis catus	PPFIBP2	VGNC	VGNC:68987
Rattus norvegicus	PPFIBP2	RGD	RGD:1565383
Bos taurus	PPFIBP2	VGNC	VGNC:58399
Macaca mulatta	PPFIBP2	VGNC	VGNC:76238
Canis familiaris	PPFIBP2	VGNC	VGNC:44848

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