2. Gene
  3. TNS4 - tensin 4 Gene

TNS4 - tensin 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CTEN; PP14434

Gene ID: 84951 | Gene type: protein coding

About TNS4

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,475,834-40,501,623 (from NCBI)

This gene has 4 transcripts (splice variants), 171 orthologues and 1 paralogue. Biased expression in skin (RPKM 23.1), esophagus (RPKM 12.4) and 6 other tissues.

Summary

Predicted to enable actin binding activity. Involved in protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]

TNS4 Products(1)

mRNA Protein Name
NM_032865.6 NP_116254.4 tensin-4 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16273093 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein localization IDA
IDA: Inferred from direct assay
17190795 GOA
Cellular Component GO Annotation Evidence Reference Source
located in focal adhesion IDA
IDA: Inferred from direct assay
17190795 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNS4 Protein Structure

SH2

SH2: SH2 domain (449 - 538)

PTB

PTB: Phosphotyrosine-binding domain (582 - 705)

  • 0
  • 200
  • 400
  • 600
  • 715 a.a.
Protein Preferred Names Protein Names

tensin-4

C terminal tensin like

TNS4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TNS4 Q8IZW8 CARD9 Homo sapiens Q9H257-2
Y2H Array
32296183
Intra
TNS4 Q8IZW8 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32296183
Intra
TNS4 Q8IZW8 CARD9 Homo sapiens Q9H257-2
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 PPP3CA Homo sapiens Q08209-2
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 PPP3CA Homo sapiens Q08209-2
Y2H Array
32296183
Intra
TNS4 Q8IZW8 KAZN Homo sapiens Q674X7-2
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 KAZN Homo sapiens Q674X7-2
Y2H Array
32296183
Intra
TNS4 Q8IZW8 EGFR Homo sapiens P00533
Protein Array
16273093
Intra
TNS4 Q8IZW8 PIH1D1 Homo sapiens Q9NWS0
Y2H Array
32296183
Intra
TNS4 Q8IZW8 PIH1D1 Homo sapiens Q9NWS0
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 PIH1D1 Homo sapiens Q9NWS0
Validated Y2H
32296183
Intra
TNS4 Q8IZW8 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
TNS4 Q8IZW8 RABEP1 Homo sapiens Q15276
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 RABEP1 Homo sapiens Q15276
Y2H Array
32296183
Intra
TNS4 Q8IZW8 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra
TNS4 Q8IZW8 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
TNS4 Q8IZW8 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
TNS4 Q8IZW8 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
TNS4 Q8IZW8 TRIM21 Homo sapiens P19474
Y2H Prey Pooling
32296183
Intra
TNS4 Q8IZW8 TRIM21 Homo sapiens P19474
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

TNS4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81488 TNS4/CTEN Antibody (YA1233) IHC-P Human
HY-P82489 Tensin 4 Antibody (YA2234) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Parotid Gland Cancer

Cancer Of Parotid Gland

Parotid Neoplasms

Malignant Neoplasm Of The Parotid

Malignant Tumor Of Parotid Gland

Parotid Cancer

Parotid Neoplasm

Parotid Gland Carcinoma

Cancer Of Parotid

Malignant Tumour Of Parotid Gland

Parotid Duct Cancer

Parotid Ductal Cancer

Parotid Glandular Cancer

Primary Malignant Neoplasm Of Parotid Gland
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14870 TNS4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TNS4 RGD RGD:1310402
Mus musculus TNS4 MGD MGI:2144377
Bos taurus TNS4 VGNC VGNC:36210
Felis catus TNS4 VGNC VGNC:66438
Canis familiaris TNS4 VGNC VGNC:47703
Macaca mulatta TNS4 VGNC VGNC:79432