2. Gene
  3. MPND - MPN domain containing Gene

MPND - MPN domain containing Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 84954 | Gene type: protein coding

About MPND

This gene has 8 transcripts (splice variants), 184 orthologues and 3 paralogues. Ubiquitous expression in colon (RPKM 12.4), duodenum (RPKM 11.4) and 25 other tissues.

Summary

Predicted to enable histone binding activity; peptidase activity; and transcription coactivator activity. Predicted to be involved in chromatin remodeling and positive regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Apr 2022]

MPND Products(3)

mRNA Protein Name
NM_001159846.3 NP_001153318.1 MPN domain-containing protein isoform 2
NM_001300862.2 NP_001287791.1 MPN domain-containing protein isoform 3
NM_032868.6 NP_116257.2 MPN domain-containing protein isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPND Protein Structure

JAB

JAB: JAB1/Mov34/MPN/PAD-1 ubiquitin protease (281 - 371)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 471 a.a.
Protein Preferred Names Protein Names

MPN domain-containing protein

MPND Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MPND Q8N594 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra MPND Q8N594 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra MPND Q8N594 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra MPND Q8N594 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra MPND Q8N594 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra MPND Q8N594 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra MPND Q8N594 HTRA2 Homo sapiens O43464
Validated Y2H
32814053
Intra MPND Q8N594 HTRA2 Homo sapiens O43464
Y2H Array
32814053
Intra MPND Q8N594 HTRA2 Homo sapiens O43464
Y2H Pooling
32814053
Intra MPND Q8N594 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra MPND Q8N594 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra MPND Q8N594 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra MPND Q8N594 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra MPND Q8N594 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra MPND Q8N594 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra MPND Q8N594 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra MPND Q8N594 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra MPND Q8N594 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Amyloidosis, Hereditary, Transthyretin-Related

Transthyretin Amyloidosis

Familial Amyloid Polyneuropathy

Ttr Amyloid Neuropathy

Transthyretin Amyloid Neuropathy

Transthyretin Amyloid Polyneuropathy

Fap

Familial Transthyretin Amyloidosis

Amyloidosis Transthyretin Related

Type I Familial Amyloid Polyneuropathy

Familial Amyloid Polyneuropathy Type I

Attrv122i Amyloidosis

Hereditary Amyloidosis, Transthyretin-Related

Amyloid Polyneuropathy, Familial

Attr Amyloidosis

Attrm Amyloidosis

Corino De Andrade'S Disease

Paramyloidosis

Transthyretin-Related Hereditary Amyloidosis

Ttr Amyloidosis

Hereditary Attr Amyloidosis

Portuguese Polyneuritic Amyloidosis

Portuguese Type Familial Amyloid Neuropathy

Swiss Type Amyloid Polyneuropathy

Type Ii Familial Amyloid Polyneuropathy

Attrv30m Amyloidosis

Attrv30m-Related Amyloidosis

Familial Amyloid Polyneuropathy, Portuguese-Swedish-Japanese Type

Attr Cardiomyopathy

Attrv122i-Related Amyloidosis

Ttr-Related Amyloid Cardiomyopathy

Ttr-Related Cardiac Amyloidosis

Transthyretin Amyloid Cardiopathy

Transthyretin-Related Familial Amyloid Cardiomyopathy

Amyloidosis, Transthyretin-Related

AMYL-TTR

Amyloidosis I

Amyloidosis Ohio Type

Amyloidosis Type 7

Amyloidosis Vii

Amyloid Polyneuropathy

Attr

Familial Amyloid Polyneuropathy Type Ii

Hereditary Amyloidosis Transthyretin-Related

Leptomeningeal Amyloidosis

Meningocerebrovascular Amyloidosis

Oculoleptomeningeal Amyloidosis

Familial Amyloid Polyneuropathies

Amyloidosis, Leptomeningeal

Senile Cardiac Amyloidosis

Amyloid Neuropathies, Familial

Danish Type Familial Amyloid Cardiomyopathy

Familial Amyloid Neuropathy, Portuguese Type

Amyloid Polyneuropathy, Swiss Type

Hereditary Oculoleptomeningeal Amyloid Angiopathy

Amyloid Neuropathies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08620 MPND Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MPND VGNC VGNC:31580
Canis familiaris MPND VGNC VGNC:43340
Felis catus MPND VGNC VGNC:63573
Macaca mulatta MPND VGNC VGNC:74831
Rattus norvegicus MPND RGD RGD:1589335
Mus musculus MPND MGD MGI:1915297
Others MPND NCBI