SLC43A1 - solute carrier family 43 member 1 Gene

Homo sapiens

Also known as LAT3; PB39; POV1; R00504

Gene ID: 8501 | Gene type: protein coding

About SLC43A1

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,484,534-57,515,702 (from NCBI)

This gene has 10 transcripts (splice variants), 262 orthologues and 1 paralogue. Ubiquitous expression in pancreas (RPKM 25.5), liver (RPKM 24.1) and 24 other tissues.

Summary

SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral Amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008]

SLC43A1 Products(2)

mRNA	Protein	Name
NM_001198810.2	NP_001185739.1	large neutral amino acids transporter small subunit 3
NM_003627.6	NP_003618.1	large neutral amino acids transporter small subunit 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-isoleucine transmembrane transporter activity	IDA IDA: Inferred from direct assay	12930836	GOA
enables L-leucine transmembrane transporter activity	IDA IDA: Inferred from direct assay	12930836	GOA
enables L-valine transmembrane transporter activity	IDA IDA: Inferred from direct assay	12930836	GOA
enables neutral L-amino acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	12930836	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-leucine transport	IDA IDA: Inferred from direct assay	12930836	GOA
involved in L-valine transmembrane transport	IDA IDA: Inferred from direct assay	12930836	GOA
involved in isoleucine transport	IDA IDA: Inferred from direct assay	12930836	GOA
acts upstream of or within negative regulation of L-leucine import across plasma membrane	IDA IDA: Inferred from direct assay	26305885	GOA
acts upstream of or within negative regulation of amino acid transport	IDA IDA: Inferred from direct assay	26305885	GOA
involved in neutral amino acid transport	IDA IDA: Inferred from direct assay	12930836	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	19443642	GOA
located in podocyte foot	IDA IDA: Inferred from direct assay	19443642	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC43A1 Protein Structure

MFS_1

0
100
200
300
400
500
559 a.a.

Protein Preferred Names

Protein Names

large neutral amino acids transporter small subunit 3

L-type amino acid transporter 3

SLC43A1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC43A1	O75387	BACH2	Homo sapiens	Q9BYV9	Validated Y2H	32296183
Intra	SLC43A1	O75387	BACH2	Homo sapiens	Q9BYV9	Y2H Array	32296183
Intra	SLC43A1	O75387	BACH2	Homo sapiens	Q9BYV9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Encephalomalacia

Seminoma

Seminoma, Pure

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13248	SLC43A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC43A1	RGD	RGD:1308229
Canis familiaris	SLC43A1	VGNC	VGNC:46415
Felis catus	SLC43A1	VGNC	VGNC:68971
Mus musculus	SLC43A1	MGD	MGI:1931352
Macaca mulatta	SLC43A1	VGNC	VGNC:77596
Bos taurus	SLC43A1	VGNC	VGNC:106933

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