1. Gene
  2. Synj1 - synaptojanin 1 Gene

Synj1 - synaptojanin 1 Gene

Rattus norvegicus
Gene ID: 85238 | Gene type: protein coding

About Synj1

Summary

Enables Phosphatase activity; protein C-terminus binding activity; and protein domain specific binding activity. Involved in several processes, including nervous system development; positive regulation of receptor-mediated endocytosis; and response to retinoic acid. Located in cytoplasm; neuron projection; and synaptic membrane. Part of clathrin coat of coated pit. Is active in parallel fiber to Purkinje cell synapse and presynapse. Colocalizes with microtubule. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 20; and developmental and epileptic encephalopathy 53. Orthologous to human SYNJ1 (synaptojanin 1). [provided by Alliance of Genome Resources, Apr 2022]

Synj1 Products(1)

mRNA Protein Name
NM_053476.3 NP_445928.2 synaptojanin-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables EH domain binding IDA
IDA: Inferred from direct assay
9428629 RGD
enables SH3 domain binding IDA
IDA: Inferred from direct assay
8552192 RGD
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
11498538 RGD
enables inositol-1,4,5-trisphosphate 5-phosphatase activity IDA
IDA: Inferred from direct assay
8552192 RGD
enables phosphatidylinositol phosphate 5-phosphatase activity IDA
IDA: Inferred from direct assay
8552192 RGD
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
IDA: Inferred from direct assay
8552192 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9238017 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
17257598 RGD
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of gliogenesis IMP
IMP: Inferred from mutant phenotype
19282871 RGD
involved in positive regulation of receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
15821731 RGD
involved in response to cytokine IMP
IMP: Inferred from mutant phenotype
19282871 RGD
involved in response to retinoic acid IMP
IMP: Inferred from mutant phenotype
19282871 RGD
Cellular Component GO Annotation Evidence Reference Source
part of clathrin coat of coated pit IDA
IDA: Inferred from direct assay
9428629 RGD
located in membrane IDA
IDA: Inferred from direct assay
8798761 RGD
located in microtubule IDA
IDA: Inferred from direct assay
9428629 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
7982917 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
7982917 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
17257598 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
9079704 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptojanin-1

synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1

Synj1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Synj1 Q62910 MYO1E Homo sapiens Q12965
Pull Down
17257598
Cross
Synj1 Q62910 SH3GL2 Homo sapiens Q99962
Pull Down
17257598
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Synj1 NCBI NCBI:8867