2. Gene
  3. PPIL4 - peptidylprolyl isomerase like 4 Gene

PPIL4 - peptidylprolyl isomerase like 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HDCME13P

Gene ID: 85313 | Gene type: protein coding

About PPIL4

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,504,495-149,546,043 (from NCBI)

This gene has 2 transcripts (splice variants), 216 orthologues and 22 paralogues. Ubiquitous expression in thyroid (RPKM 15.0), gall bladder (RPKM 11.6) and 25 other tissues.

Summary

This gene is a member of the Cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and Infection of HIV-1 virions. [provided by RefSeq, Jul 2008]

PPIL4 Products(1)

mRNA Protein Name
NM_139126.4 NP_624311.1 peptidyl-prolyl cis-trans isomerase-like 4
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPIL4 Protein Structure

Pro_isomerase

Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (5 - 159)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (242 - 312)

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  • 492 a.a.
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase-like 4

PPIase

PPIL4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PPIL4 Q8WUA2 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
PPIL4 Q8WUA2 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
PPIL4 Q8WUA2 DLG2 Homo sapiens Q15700
Y2H Prey Pooling
32296183
Intra
PPIL4 Q8WUA2 DLG2 Homo sapiens Q15700
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10957 PPIL4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PPIL4 VGNC VGNC:44857
Mus musculus PPIL4 MGD MGI:1914668
Rattus norvegicus PPIL4 RGD RGD:1311051
Bos taurus PPIL4 VGNC VGNC:33204
Macaca mulatta PPIL4 VGNC VGNC:76031
Felis catus PPIL4 VGNC VGNC:102487