DLG2 - discs large MAGUK scaffold protein 2 Gene

Homo sapiens

Also known as PSD93; PSD-93; PPP1R58; chapsyn-110

Gene ID: 1740 | Gene type: protein coding

About DLG2

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:83,455,012-85,628,373 (from NCBI)

This gene has 50 transcripts (splice variants), 219 orthologues and 3 paralogues. Biased expression in brain (RPKM 9.7), adrenal (RPKM 2.3) and 5 other tissues.

Summary

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]

DLG2 Products(26)

mRNA	Protein	Name
NM_001142699.3	NP_001136171.1	disks large homolog 2 isoform 1
NM_001142700.2	NP_001136172.1	disks large homolog 2 isoform 3
NM_001142702.2	NP_001136174.1	disks large homolog 2 isoform 4
NM_001206769.2	NP_001193698.1	disks large homolog 2 isoform 5
NM_001300983.1	NP_001287912.1	disks large homolog 2 isoform 6
NM_001351274.2	NP_001338203.1	disks large homolog 2 isoform 7
NM_001351275.2	NP_001338204.1	disks large homolog 2 isoform 8
NM_001351276.2	NP_001338205.1	disks large homolog 2 isoform 9
NM_001364.3	NP_001355.2	disks large homolog 2 isoform 2
NM_001377966.1	NP_001364895.1	disks large homolog 2 isoform 10
NM_001377967.1	NP_001364896.1	disks large homolog 2 isoform 11
NM_001377968.1	NP_001364897.1	disks large homolog 2 isoform 12
NM_001377970.1	NP_001364899.1	disks large homolog 2 isoform 13
NM_001377971.1	NP_001364900.1	disks large homolog 2 isoform 14
NM_001377972.1	NP_001364901.1	disks large homolog 2 isoform 15
NM_001377973.1	NP_001364902.1	disks large homolog 2 isoform 16
NM_001377974.1	NP_001364903.1	disks large homolog 2 isoform 17
NM_001377975.1	NP_001364904.1	disks large homolog 2 isoform 18
NM_001377976.1	NP_001364905.1	disks large homolog 2 isoform 19
NM_001377977.1	NP_001364906.1	disks large homolog 2 isoform 20
NM_001377978.1	NP_001364907.1	disks large homolog 2 isoform 21
NM_001377979.1	NP_001364908.1	disks large homolog 2 isoform 22
NM_001377980.1	NP_001364909.1	disks large homolog 2 isoform 23
NM_001377981.1	NP_001364910.1	disks large homolog 2 isoform 24
NM_001377982.1	NP_001364911.1	disks large homolog 2 isoform 25
NM_001377983.1	NP_001364912.1	disks large homolog 2 isoform 26

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase binding	IDA IDA: Inferred from direct assay	21119615	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15304517	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DLG2 Protein Structure

MAGUK_N_PEST

PDZ

PDZ_assoc

PDZ

SH3_2

Guanylate_kin

0
200
400
600
800
870 a.a.

Protein Preferred Names

Protein Names

disks large homolog 2

channel-associated protein of synapse-110

DLG2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DLG2	Q15700	RPF2	Homo sapiens	Q9H7B2	Validated Y2H	32296183
Intra	DLG2	Q15700	FA2H	Homo sapiens	Q7L5A8	Validated Y2H	32296183
Intra	DLG2	Q15700	DLGAP1	Homo sapiens	Q6IS01	Validated Y2H	32296183
Intra	DLG2	Q15700	DLGAP2	Homo sapiens	Q9P1A6-3	Validated Y2H	32296183
Intra	DLG2	Q15700	PPIL4	Homo sapiens	Q8WUA2	Validated Y2H	32296183
Intra	DLG2	Q15700	SERPINB13	Homo sapiens	Q9UIV8	Validated Y2H	32296183
Intra	DLG2	Q15700	PLEKHA2	Homo sapiens	Q9HB19	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

DLG2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83442	PSD93 Antibody (YA3187)	WB, IP	Human, Rat

Related Diseases

Diseases

Alias

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Childhood Osteosarcoma

Pediatric Osteosarcoma

Coffin-Siris Syndrome 1

Coffin-Siris Syndrome	Fifth Digit Syndrome
Css	CSS1
Mrd12	Mental Retardation, Autosomal Dominant 12
Hhid	Dwarfism-Onychodysplasia
Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features	Autosomal Dominant Mental Retardation 12
Short Stature-Onychodysplasia.	Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx
Mental Retardation With Hypoplastic Fifth Fingernails And Toenails	Short Stature-Onychodysplasia
Coffin-Siris Syndrome, Type 1	Mental Retardation, Autosomal Dominant, Type 12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03797	DLG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DLG2	MGD	MGI:1344351
Rattus norvegicus	DLG2	RGD	RGD:619895
Macaca mulatta	DLG2	VGNC	VGNC:81388
Canis familiaris	DLG2	VGNC	VGNC:39978

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