CHST1 - carbohydrate sulfotransferase 1 Gene

Homo sapiens

Also known as C6ST; KSST; GST-1; KS6ST; KSGal6ST

Gene ID: 8534 | Gene type: protein coding

About CHST1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:45,647,689-45,665,622 (from NCBI)

This gene has 3 transcripts (splice variants), 249 orthologues and 6 paralogues. Biased expression in brain (RPKM 12.8), thyroid (RPKM 2.7) and 6 other tissues.

Summary

This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded Enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011]

CHST1 Products(1)

mRNA	Protein	Name
NM_003654.6	NP_003645.1	carbohydrate sulfotransferase 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables keratan sulfotransferase activity	IDA IDA: Inferred from direct assay	9405439	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sulfotransferase activity	IDA IDA: Inferred from direct assay	10330415	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in galactose metabolic process	IDA IDA: Inferred from direct assay	10330415	GOA
involved in keratan sulfate biosynthetic process	IDA IDA: Inferred from direct assay	17690104	GOA
involved in keratan sulfate metabolic process	IDA IDA: Inferred from direct assay	9405439	GOA
involved in sulfur compound metabolic process	IDA IDA: Inferred from direct assay	10330415	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHST1 Protein Structure

Sulfotransfer_1

0
100
200
300
411 a.a.

Protein Preferred Names

Protein Names

carbohydrate sulfotransferase 1

Keratan sulfotransferase

CHST1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CHST1	O43916	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	CHST1	O43916	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	CHST1	O43916	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	CHST1	O43916	STOM	Homo sapiens	P27105	Validated Y2H	32296183
Intra	CHST1	O43916	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	CHST1	O43916	STOM	Homo sapiens	P27105	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Macular Dystrophy, Corneal

Macular Corneal Dystrophy	MCD
Corneal Dystrophy, Macular Type	Groenouw Type Ii Corneal Dystrophy
Fehr Corneal Dystrophy	Macular Dystrophy, Corneal Type 1
Mcdc1	Macular Corneal Dystrophy Type Ii
Macular Corneal Dystrophy, Type Ii	Macular Corneal Dystrophy, Type I
Mcdc1, Formerly	Macular Dystrophy, Corneal, 1
Macular Corneal Dystrophy Type 1	Corneal Dystrophy Groenouw Type Ii
Corneal Dystrophy Macular Type	Macular Corneal Dystrophy Type I
Dystrophy, Macular, Corneal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02681	CHST1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CHST1	MGD	MGI:1924219
Rattus norvegicus	CHST1	RGD	RGD:1308142
Macaca mulatta	CHST1	VGNC	VGNC:71055
Bos taurus	CHST1	VGNC	VGNC:27337
Canis familiaris	CHST1	VGNC	VGNC:39249
Felis catus	CHST1	VGNC	VGNC:81998
Others	CHST1	NCBI

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