GPX8 - glutathione peroxidase 8 (putative) Gene

Homo sapiens

Also known as GPx-8; UNQ847; EPLA847; GSHPx-8

Gene ID: 493869 | Gene type: protein coding

About GPX8

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,160,171-55,167,297 (from NCBI)

This gene has 8 transcripts (splice variants), 213 orthologues and 7 paralogues. Broad expression in placenta (RPKM 14.8), endometrium (RPKM 12.4) and 20 other tissues.

Summary

Enables peroxidase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Apr 2022]

GPX8 Products(4)

mRNA	Protein	Name
NM_001008397.4	NP_001008398.2	probable glutathione peroxidase 8 isoform a
NM_001306197.2	NP_001293126.1	probable glutathione peroxidase 8 isoform b
NM_001306198.2	NP_001293127.1	probable glutathione peroxidase 8 isoform c
NM_001306201.2	NP_001293130.1	probable glutathione peroxidase 8 isoform d

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables peroxidase activity	EXP EXP: Inferred from Experiment	21215271	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPX8 Protein Structure

GSHPx

0
100
209 a.a.

Protein Preferred Names

Protein Names

probable glutathione peroxidase 8

GPX8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GPX8	Q8TED1	SLC35B4	Homo sapiens	Q969S0	Validated Y2H	32296183
Intra	GPX8	Q8TED1	SLC41A2	Homo sapiens	Q96JW4	Validated Y2H	32296183
Intra	GPX8	Q8TED1	SLC30A3	Homo sapiens	Q99726	Validated Y2H	32296183
Intra	GPX8	Q8TED1	TMPRSS4	Homo sapiens	Q9NRS4	Validated Y2H	32296183
Intra	GPX8	Q8TED1	PAQR5	Homo sapiens	Q9NXK6	Validated Y2H	32296183
Intra	GPX8	Q8TED1	MARCHF2	Homo sapiens	Q9P0N8	Validated Y2H	32296183
Intra	GPX8	Q8TED1	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	32296183
Intra	GPX8	Q8TED1	GAPDHS	Homo sapiens	O14556	Anti Tag CoIP	28514442
Intra	GPX8	Q8TED1	GAPDHS	Homo sapiens	O14556	Anti Tag CoIP	33961781
Intra	GPX8	Q8TED1	TMEM109	Homo sapiens	Q9BVC6	Validated Y2H	32296183
Intra	GPX8	Q8TED1	MGST2	Homo sapiens	Q99735	Validated Y2H	32296183
Intra	GPX8	Q8TED1	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	GPX8	Q8TED1	CFHR5	Homo sapiens	Q9BXR6	Validated Y2H	32296183
Intra	GPX8	Q8TED1	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	GPX8	Q8TED1	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	GPX8	Q8TED1	PGAP2	Homo sapiens	Q9UHJ9-5	Validated Y2H	32296183
Intra	GPX8	Q8TED1	TMEM97	Homo sapiens	Q5BJF2	Y2H Array	32296183
Intra	GPX8	Q8TED1	LNPEP	Homo sapiens	Q9UIQ6-2	Validated Y2H	32296183
Intra	GPX8	Q8TED1	FAXDC2	Homo sapiens	Q96IV6	Validated Y2H	32296183
Intra	GPX8	Q8TED1	MAN2B2	Homo sapiens	Q9Y2E5	Validated Y2H	32296183
Intra	GPX8	Q8TED1	TMEM243	Homo sapiens	Q9BU79	Y2H Prey Pooling	32296183
Intra	GPX8	Q8TED1	TMEM243	Homo sapiens	Q9BU79	Validated Y2H	32296183
Intra	GPX8	Q8TED1	ST6GAL2	Homo sapiens	Q96JF0-2	Validated Y2H	32296183
Intra	GPX8	Q8TED1	SLC13A3	Homo sapiens	Q8WWT9	Validated Y2H	32296183
Intra	GPX8	Q8TED1	SYT15	Homo sapiens	Q9BQS2-2	Validated Y2H	32296183
Intra	GPX8	Q8TED1	CORIN	Homo sapiens	Q9Y5Q5	Validated Y2H	32296183
Intra	GPX8	Q8TED1	MARCHF5	Homo sapiens	Q9NX47	Validated Y2H	32296183
Intra	GPX8	Q8TED1	SERINC1	Homo sapiens	Q9NRX5	Validated Y2H	32296183
Intra	GPX8	Q8TED1	NINJ1	Homo sapiens	Q92982	Validated Y2H	32296183
Intra	GPX8	Q8TED1	AQP3	Homo sapiens	Q92482	Validated Y2H	32296183
Intra	GPX8	Q8TED1	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	GPX8	Q8TED1	FAM3C	Homo sapiens	Q92520	Validated Y2H	32296183
Intra	GPX8	Q8TED1	PLLP	Homo sapiens	Q9Y342	Validated Y2H	32296183
Intra	GPX8	Q8TED1	ALG8	Homo sapiens	Q9BVK2	Validated Y2H	32296183
Intra	GPX8	Q8TED1	RND1	Homo sapiens	Q92730	Validated Y2H	32296183
Intra	GPX8	Q8TED1	HHATL	Homo sapiens	Q9HCP6	Validated Y2H	32296183
Intra	GPX8	Q8TED1	TIMMDC1	Homo sapiens	Q9NPL8	Validated Y2H	32296183
Intra	GPX8	Q8TED1	GYPA	Homo sapiens	P02724	Y2H Array	32296183
Intra	GPX8	Q8TED1	BCL2L2	Homo sapiens	Q92843	Validated Y2H	32296183
Intra	GPX8	Q8TED1	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	GPX8	Q8TED1	NEU1	Homo sapiens	Q99519	Validated Y2H	32296183
Intra	GPX8	Q8TED1	VTI1B	Homo sapiens	Q9UEU0	Validated Y2H	32296183
Intra	GPX8	Q8TED1	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	GPX8	Q8TED1	TMEM19	Homo sapiens	Q96HH6	Validated Y2H	32296183
Intra	GPX8	Q8TED1	KLRG1	Homo sapiens	Q96E93	Validated Y2H	32296183
Intra	GPX8	Q8TED1	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	GPX8	Q8TED1	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
Intra	GPX8	Q8TED1	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	GPX8	Q8TED1	DNAJC30	Homo sapiens	Q96LL9	Validated Y2H	32296183
Intra	GPX8	Q8TED1	DOLK	Homo sapiens	Q9UPQ8	Validated Y2H	32296183
Intra	GPX8	Q8TED1	BTN2A2	Homo sapiens	Q8WVV5	Validated Y2H	32296183
Intra	GPX8	Q8TED1	SELENOK	Homo sapiens	Q9Y6D0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency

Favism	Favism, Susceptibility To
Hemolytic Anemia, G6pd Deficient	Class I Glucose-6-Phosphate Dehydrogenase Deficiency
Class I G6pd Deficiency	Severe Hemolytic Anemia Due To G6pd Deficiency
Anemia, Non-Spherocytic Hemolytic, Due To G6pd Deficiency	NSHA
G6pd Deficient Hemolytic Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05771	GPX8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GPX8	VGNC	VGNC:110461
Mus musculus	GPX8	MGD	MGI:1916840
Felis catus	GPX8	VGNC	VGNC:102217
Rattus norvegicus	GPX8	RGD	RGD:1307506

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