CAMK1 - calcium/calmodulin dependent protein kinase I Gene

Homo sapiens

Also known as CAMKI

Gene ID: 8536 | Gene type: protein coding

About CAMK1

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,757,347-9,769,947 (from NCBI)

This gene has 6 transcripts (splice variants), 270 orthologues and 22 paralogues. Broad expression in adrenal (RPKM 42.3), fat (RPKM 25.3) and 22 other tissues.

Summary

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/Calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the Enzyme and indirectly promotes the phosphorylation and synergistic activation of the Enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]

CAMK1 Products(1)

mRNA	Protein	Name
NM_003656.5	NP_003647.1	calcium/calmodulin-dependent protein kinase type 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17442826	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	23867755	GOA
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	23867755	GOA
involved in positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	18184567	GOA
involved in positive regulation of muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	11081517	GOA
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	17442826	GOA
involved in positive regulation of protein export from nucleus	IDA IDA: Inferred from direct assay	23867755	GOA
involved in positive regulation of protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	17442826	GOA
involved in positive regulation of synapse structural plasticity	IMP IMP: Inferred from mutant phenotype	18184567	GOA
involved in positive regulation of syncytium formation by plasma membrane fusion	IMP IMP: Inferred from mutant phenotype	23867755	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23867755	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11114197	GOA
involved in regulation of muscle cell differentiation	IDA IDA: Inferred from direct assay	11114197	GOA
involved in regulation of protein binding	IDA IDA: Inferred from direct assay	11114197	GOA
involved in regulation of protein localization	IDA IDA: Inferred from direct assay	11114197	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMK1 Protein Structure

Pkinase

0
100
200
300
370 a.a.

Protein Preferred Names

Protein Names

calcium/calmodulin-dependent protein kinase type 1

caM kinase I alpha

CAMK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CAMK1	Q14012	CAMK1D	Homo sapiens	Q8IU85	Pull Down	32707033
Intra	CAMK1	Q14012	ATXN1	Homo sapiens	P54253	Y2H Prey Pooling	32296183
Intra	CAMK1	Q14012	ATXN1	Homo sapiens	P54253	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CAMK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7714	CAMKI alpha/CAMK1 Protein, Human (HEK293, His)	Q14012 (M1-L370)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148913	CS587	Inhibitor	98.11%	Unkown
HY-148907	CS640	Inhibitor	99.43%	Unkown
HY-143898	PIM1-IN-4	Inhibitor	/	Unkown
HY-156871	CAMK1D-IN-1		/	Unkown
HY-P10282	Synapsin I-(3-13)		/	Unkown
HY-RS01851	CAMK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01852	CAMK1D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01853	CAMK1G Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CAMK1	VGNC	VGNC:60328
Rattus norvegicus	CAMK1	RGD	RGD:629473
Mus musculus	CAMK1	MGD	MGI:1098535
Bos taurus	CAMK1	VGNC	VGNC:26719
Macaca mulatta	CAMK1	VGNC	VGNC:70522
Canis familiaris	CAMK1	VGNC	VGNC:38677
Others	CAMK1	NCBI

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