Prkd1 - protein kinase D1 Gene

Rattus norvegicus

Also known as Pkcm; Prkcm; nPKC-D1; nPKC-mu

Gene ID: 85421 | Gene type: protein coding

About Prkd1

Primary_assembly 6: 67,725,905-68,039,042 reverse strand.mRatBN7.2:CM026979.1

This gene has 3 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 8 phenotypes. Biased expression in Kidney (RPKM 52.3), Heart (RPKM 33.2) and 8 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in intracellular signal transduction. Predicted to be located in several cellular components, including autophagosome membrane; cell-cell junction; and trans-Golgi network. Orthologous to human PRKD1 (protein kinase D1). [provided by Alliance of Genome Resources, Apr 2022]

Prkd1 Products(2)

mRNA	Protein	Name
NM_001412095.1	NP_001399024.1	serine/threonine-protein kinase D1 isoform 2
NM_001276715.2	NP_001263644.1	serine/threonine-protein kinase D1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	25889640	RGD
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	15652511	RGD
enables protein kinase activity	IDA IDA: Inferred from direct assay	16648482	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12057008	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to angiotensin	IDA IDA: Inferred from direct assay	15652511	RGD
involved in cellular response to endothelin	IDA IDA: Inferred from direct assay	15652511	RGD
involved in cellular response to norepinephrine stimulus	IDA IDA: Inferred from direct assay	15652511	RGD
involved in cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	16648482	RGD
involved in cellular response to organic cyclic compound	IMP IMP: Inferred from mutant phenotype	25889640	RGD
involved in cellular response to phorbol 13-acetate 12-myristate	IDA IDA: Inferred from direct assay	15652511	RGD
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	12057008	RGD
involved in positive regulation of cell size	IMP IMP: Inferred from mutant phenotype	16648482	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25889640	RGD
involved in positive regulation of peptide hormone secretion	IMP IMP: Inferred from mutant phenotype	16648482	RGD
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	21041300	RGD
involved in positive regulation of protein export from nucleus	IMP IMP: Inferred from mutant phenotype	16648482	RGD
involved in positive regulation of sarcomere organization	IMP IMP: Inferred from mutant phenotype	16648482	RGD
involved in regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril	IMP IMP: Inferred from mutant phenotype	21041300	RGD
involved in response to norepinephrine	IDA IDA: Inferred from direct assay	16648482	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	15652511	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	25889640	RGD
located in membrane	IDA IDA: Inferred from direct assay	15652511	RGD
located in nucleus	IDA IDA: Inferred from direct assay	16648482	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15652511	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkd1 Protein Structure

C1_PKD1_rpt1

C1_PKD1_rpt2

PH_PKD

STKc_PKD

0
200
400
600
800
928 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase D1

protein kinase C mu type

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11144	PRKD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11145	Prkd1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11146	Prkd1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkd1	NCBI	NCBI:5587

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