SELENOI - selenoprotein I Gene

Homo sapiens

Also known as EPT1; SELI; SEPI; SPG81

Gene ID: 85465 | Gene type: protein coding

About SELENOI

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,346,143-26,395,885 (from NCBI)

This gene has 4 transcripts (splice variants), 211 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 12.3), small intestine (RPKM 10.6) and 25 other tissues.

Summary

The multi-pass transmembrane protein encoded by this gene belongs to the CDP-alcohol phosphatidyltransferase class-I family. It catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine, which is involved in the formation and maintenance of vesicular membranes, regulation of lipid metabolism, and protein folding. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]

SELENOI Products(1)

mRNA	Protein	Name
NM_033505.4	NP_277040.1	ethanolaminephosphotransferase 1

SELENOI Protein Structure

CDP-OH_P_transf

0
100
200
300
397 a.a.

Protein Preferred Names

Protein Names

ethanolaminephosphotransferase 1

ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)

Recombinant SELENOI Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70905	EPT1 Protein, Human (GST)	Q9C0D9 (M1-P50)	≥95%

Related Diseases

Diseases

Alias

Spastic Paraplegia 81, Autosomal Recessive

SPG81	Autosomal Recessive Complex Spastic Paraplegia Due To Kennedy Pathway Dysfunction
Autosomal Recessive Complex Spg Due To Kennedy Pathway Dysfunction	Hereditary Spastic Paraplegia 81
Spastic Paraplegia 81 Autosomal Recessive	Doid:0112349

Childhood Hepatocellular Carcinoma

Pediatric Hepatocellular Carcinoma	Childhood Carcinoma Of Liver Cell
Childhood Hepatoma	Childhood Liver Cell Carcinoma
Pediatric Carcinoma Of Liver Cell	Pediatric Hepatoma
Pediatric Liver Cell Carcinoma	Childhood-Onset Hcc
Childhood-Onset Hepatocellular Carcinoma	Pediatric Hcc
Childhood Liver Cancer

Spastic Paraplegia 83, Autosomal Recessive

SPG83	Hereditary Spastic Paraplegia 83
Spastic Paraplegia 83 Autosomal Recessive	Doid:0112346
Paraplegia, Spastic, Type 83, Autosomal Recessive

Spastic Paraplegia 82, Autosomal Recessive

SPG82	Hereditary Spastic Paraplegia 82
Spastic Paraplegia 82 Autosomal Recessive	Doid:0112343

Adult Hepatocellular Carcinoma

Adult Primary Hepatocellular Carcinoma	Adult Hepatoma
Adult Hcc

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12636	SELENOI Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SELENOI	VGNC	VGNC:45982
Bos taurus	SELENOI	VGNC	VGNC:97309
Mus musculus	SELENOI	MGD	MGI:107898
Rattus norvegicus	SELENOI	RGD	RGD:1560938
Macaca mulatta	SELENOI	VGNC	VGNC:77335
Felis catus	SELENOI	VGNC	VGNC:81218

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