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  3. CDC14A - cell division cycle 14A Gene

CDC14A - cell division cycle 14A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as cdc14; DFNB32; DFNB35; hCDC14; DFNB105

Gene ID: 8556 | Gene type: protein coding

About CDC14A

Cytogenetic location: 1p21.2 Genomic coordinates (GRCh38): 1:100,345,001-100,520,277 (from NCBI)

This gene has 14 transcripts (splice variants), 263 orthologues, 8 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 5.6), bone marrow (RPKM 3.3) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the dual specificity protein tyrosine Phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine Phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

CDC14A Products(6)

mRNA Protein Name
NM_001319210.2 NP_001306139.1 dual specificity protein phosphatase CDC14A isoform 4
NM_001319211.2 NP_001306140.1 dual specificity protein phosphatase CDC14A isoform 5
NM_001319212.2 NP_001306141.1 dual specificity protein phosphatase CDC14A isoform 6
NM_003672.4 NP_003663.2 dual specificity protein phosphatase CDC14A isoform 1
NM_033312.3 NP_201569.1 dual specificity protein phosphatase CDC14A isoform 2
NM_033313.3 NP_201570.1 dual specificity protein phosphatase CDC14A isoform 3

CDC14A Protein Structure

DSPn

DSPn: Dual specificity protein phosphatase, N-terminal half (12 - 152)

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (217 - 325)

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  • 594 a.a.
Protein Preferred Names Protein Names

dual specificity protein phosphatase CDC14A

CDC10 (cell division cycle 10, S. cerevisiae, homolog)

Related Diseases

Diseases Alias
Deafness, Autosomal Recessive 32, With Or Without Immotile Sperm

DFNB32

Hearing Impairment Infertile Male Syndrome

Hiims

Deafness, Autosomal Recessive 105, Formerly

Dfnb105, Formerly

Deafness, Autosomal Recessive, 32, With Or Without Immotile Sperm

Deafness, Autosomal Recessive 105

Hearing Impairment And Infertile Male Syndrome
Autosomal Recessive Nonsyndromic Deafness 32

Deafness, Autosomal Recessive 32

Autosomal Recessive Deafness 105

Autosomal Recessive Deafness 32

Dfnb32

Hearing Impairment Infertile Male Syndrome

Hiims

Deafness, Autosomal Recessive, Type 32
Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency
Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb

Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb

Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb

Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb

Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb
Ear Malformation

Cup Ear
Rare Genetic Deafness

Rare Genetic Hearing Loss
Spermatogenic Failure 21

SPGF21
Myopathy, Centronuclear, 2

Myopathy, Centronuclear, Autosomal Recessive

Autosomal Recessive Centronuclear Myopathy

CNM2

Centronuclear Myopathy 2

Ar-Cnm

Myotubular Myopathy, Autosomal Recessive

Autosomal Recessive Myotubular Myopathy

Centronuclear Myopathy Autosomal Recessive

Myopathy, Centronuclear, Type 2
Pulmonary Immaturity

Primary Atelectasis Of Newborn

Primary Atelectasis, In Perinatal Period

Primary Failure To Expand Terminal Respiratory Units

Immature Lungs

Primary Atelectasis

Pulmonary Immaturity Nos

Lung Lobe Hypoplasia, Associated With Short Gestation

Lung Nonexpansion

Premature Lungs

Pulmonary Hypoplasia Associated With Short Gestation

Failure Of Expansion Of Terminal Respiratory Units

Primary Atelectasis Of Fetus Or Newborn

Primary Atelectasis In Perinatal Period
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-161673 CDC14A/B-IN-1 Inhibitor / Unkown
HY-RS02285 CDC14A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CDC14A VGNC VGNC:27059
Rattus norvegicus CDC14A RGD RGD:1304649
Felis catus CDC14A VGNC VGNC:60647
Macaca mulatta CDC14A VGNC VGNC:70791
Mus musculus CDC14A MGD MGI:2442676
Canis familiaris CDC14A VGNC VGNC:38986