2. Gene
  3. GALP - galanin like peptide Gene

GALP - galanin like peptide Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 85569 | Gene type: protein coding

About GALP

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:56,176,008-56,185,775 (from NCBI)

This gene has 3 transcripts (splice variants) and 52 orthologues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the Galanin family of neuropeptides. The encoded protein binds Galanin receptors 1, 2 and 3 with the highest affinity for Galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.[provided by RefSeq, Nov 2014]

GALP Products(2)

mRNA Protein Name
NM_001145546.2 NP_001139018.1 galanin-like peptide isoform 2 precursor
NM_033106.4 NP_149097.1 galanin-like peptide isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
IMP: Inferred from mutant phenotype
23537644 GOA
involved in defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
23537644 GOA
involved in modulation of process of another organism IMP
IMP: Inferred from mutant phenotype
23537644 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GALP Protein Structure

Galanin

Galanin: Galanin (33 - 45)

  • 0
  • 100
  • 116 a.a.
Protein Preferred Names Protein Names

galanin-like peptide

alarin

Related Diseases

Diseases Alias
Ganglioneuroblastoma
Ganglioneuroma
Inflammatory Bowel Disease 25

Early Onset Autosomal Recessive Inflammatory Bowel Disease 25

Ibd25

Inflammatory Bowel Disease 25, Autosomal Recessive
Spherocytosis, Type 3

Hereditary Spherocytosis Type 3

SPH3

Hs3

Spherocytosis, Hereditary, 3

Hereditary Spherocytosis 3

Spherocytosis 3
Cardiomyopathy, Dilated, 1p

Dilated Cardiomyopathy 1p

CMD1P

Cardiomyopathy, Dilated 1p

Cardiomyopathy, Dilated, Type 1p
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P5894 human GALP (3-32) Antagonist / Unkown
HY-RS05263 GALP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-127016 Manninotrionate potassium / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GALP VGNC VGNC:41099
Mus musculus GALP MGD MGI:2663979
Rattus norvegicus GALP RGD RGD:620187
Macaca mulatta GALP VGNC VGNC:72775