PDLIM4 - PDZ and LIM domain 4 Gene

Homo sapiens

Also known as RIL

Gene ID: 8572 | Gene type: protein coding

About PDLIM4

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:132,257,696-132,273,454 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues, 7 paralogues and is associated with 1 phenotype. Ubiquitous expression in endometrium (RPKM 8.6), prostate (RPKM 6.1) and 21 other tissues.

Summary

This gene encodes a protein which may be involved in bone development. Mutations in this gene are associated with susceptibility to osteoporosis. [provided by RefSeq, Nov 2009]

PDLIM4 Products(2)

mRNA	Protein	Name
NM_001131027.2	NP_001124499.1	PDZ and LIM domain protein 4 isoform 2
NM_003687.4	NP_003678.2	PDZ and LIM domain protein 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-actinin binding	IPI IPI: Inferred from physical interaction	20120020	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10826496	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	25158098	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	19307596	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	21636573	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21636573	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	21636573	GOA
part of filamentous actin	IDA IDA: Inferred from direct assay	10826496	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	10826496	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10826496	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19307596	GOA
located in stress fiber	IDA IDA: Inferred from direct assay	21636573	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDLIM4 Protein Structure

PDZ

LIM

0
100
200
300
330 a.a.

Protein Preferred Names

Protein Names

PDZ and LIM domain protein 4

LIM domain protein

Related Diseases

Diseases

Alias

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Bone Mineral Density Quantitative Trait Locus 15

Osteoporosis	BMND15
Osteoporosis, Susceptibility To	Metaphyseal Fracture
Metaphyseal Fracture, Susceptibility To	Compression Fracture
Compression Fracture, Susceptibility To	Metaphyseal Fractures
Fractures, Compression

Castration-Resistant Prostate Carcinoma

Prostatic Neoplasms, Castration-Resistant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10282	PDLIM4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PDLIM4	RGD	RGD:3575
Bos taurus	PDLIM4	VGNC	VGNC:32710
Canis familiaris	PDLIM4	VGNC	VGNC:44386
Felis catus	PDLIM4	VGNC	VGNC:64091
Macaca mulatta	PDLIM4	VGNC	VGNC:75809
Mus musculus	PDLIM4	MGD	MGI:1353470

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