TNFRSF25 - TNF receptor superfamily member 25 Gene

Homo sapiens

Also known as DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; GEF720; WSL-LR; PLEKHG5; TNFRSF12

Gene ID: 8718 | Gene type: protein coding

About TNFRSF25

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,460,786-6,466,173 (from NCBI)

This gene has 21 transcripts (splice variants), 461 orthologues and 21 paralogues. Broad expression in skin (RPKM 23.6), spleen (RPKM 13.2) and 19 other tissues.

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell Apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]

TNFRSF25 Products(6)

mRNA	Protein	Name
NM_001039664.2	NP_001034753.1	tumor necrosis factor receptor superfamily member 25 isoform 12 precursor
NM_003790.3	NP_003781.1	tumor necrosis factor receptor superfamily member 25 isoform 2 precursor
NM_148965.2	NP_683866.1	tumor necrosis factor receptor superfamily member 25 isoform 1 precursor
NM_148966.2	NP_683867.1	tumor necrosis factor receptor superfamily member 25 isoform 3 precursor
NM_148967.2	NP_683868.1	tumor necrosis factor receptor superfamily member 25 isoform 4 precursor
NM_148970.2	NP_683871.1	tumor necrosis factor receptor superfamily member 25 isoform 7 precursor

TNFRSF25 Protein Structure

Death

0
100
200
300
417 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 25

Guanine nucleotide exchange factor 720

Recombinant TNFRSF25 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72666	DR3/TNFRSF25 Protein, Human (HEK293, Fc)	Q93038 (Q25-F201)	≥95%
HY-P77522	DR3/TNFRSF25 Protein, Human (Biotinylated, HEK293, Fc)	Q93038 (Q25-Q199)	≥95%

Related Diseases

Diseases

Alias

Type 1 Diabetes Mellitus 5

Diabetes Mellitus, Insulin-Dependent, 5	Latent Autoimmune Diabetes In Adults
IDDM5	Insulin-Dependent Diabetes Mellitus 5
T1D5	Lada
Type 1.5 Diabetes	Diabetes Mellitus, Insulin-Dependent, Type 5

Pemphigoid Gestationis

Herpes Gestationis	Gestational Pemphigoid
Gestational Herpes

Autoimmune Disease Of Endocrine System

Adrenal Cortical Hypofunction

Adrenal Cortical Insufficiency

Corticoadrenal Insufficiency

Juvenile Dermatitis Herpetiformis

Amelogenesis Imperfecta, Type Ib

AI1B	Aih2
Amelogenesis Imperfecta Type 1b	Amelogenesis Imperfecta Type Ib
Hereditary Localized Enamel Hypoplasia	Amelogenesis Imperfecta - Hypoplastic Autosomal Dominant - Local
Amelogenesis Imperfecta, Hypoplastic Local, Autosomal Dominant	Enamel Hypoplasia, Hereditary Localized
Autosomal Dominant Hypoplastic Local Amelogenesis Imperfecta	Amelogenesis Imperfecta 1b
Amelogenesis Imperfecta Hypoplastic 2	Amelogenesis Imperfecta Hypoplastic Local Autosomal Dominant

Amelogenesis Imperfecta, Type Ie

Aih1	Amelogenesis Imperfecta Type 1e
AI1E	Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1
Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth	Enamel Hypoplasia, X-Linked
Amelogenesis Imperfecta Type Ie	Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1
Enamel Hypoplasia X-Linked	Amelogenesis Imperfecta, X-Linked 1
Amelogenesis Imperfecta, Type 1e	Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth
X-Linked Amelogenesis Imperfecta 1	X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1
X-Linked Enamel Hypoplasia	Amelogenesis Imperfecta X-Linked 1
Amelogenesis Imperfecta 1e	Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e
Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth	Xai
X-Linked Amelogenesis Imperfecta	Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2

Thyroiditis

Inflammation Of Thyroid

Thyroiditis Nos

Haemophilus Meningitis

Meningitis, Haemophilus

Type 1 Diabetes Mellitus 17

Diabetes Mellitus, Insulin-Dependent, 17	Iddm17
Insulin-Dependent Diabetes Mellitus 17	TID17
Insulin-Dependent Diabetes Mellitus-17

Heart Block, Congenital

Congenital Heart Block	Heart Block Congenital
Congenital Atrioventricular Block

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus Type 1
IDDM	Type 1 Diabetes
Insulin-Dependent Diabetes Mellitus	T1D
Juvenile-Onset Diabetes	Jod
Diabetes Mellitus, Type 1	Diabetes Mellitus, Insulin-Dependent-1
Type I Diabetes Mellitus	Autoimmune Diabetes
Juvenile Diabetes	Juvenile-Onset Diabetes Mellitus
Diabetes, Insulin Dependent	Insulin-Dependent Diabetes Mellitus-1
Diabetes Mellitus Insulin-Dependent	Diabetes Autoimmune
Diabetes Mellitus, Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 1, Susceptibility To
Diabetes Type 1	Type I Diabetes
Diabetes, Autoimmune	T1dm - [Type 1 Diabetes Mellitus]
Iddm - [Insulin Dependent Diabetes Mellitus]	Type 1 Iddm
Juvenile Diabetes Mellitus Without Compications	Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications
Juvenile-Onset Diabetes Mellitus Without Compications	Ketosis-Prone Diabetes Mellitus Without Compications
Juvenile-Onset-Type Diabetes Mellitus Without Compications

Immunoglobulin Alpha Deficiency

Iga Deficiency	Gamma-A-Globulin Deficiency
Immunoglobulin A Deficiency

Autoimmune Polyendocrine Syndrome, Type Ii

Schmidt Syndrome	Autoimmune Polyendocrine Syndrome Type 2
APS2	Autoimmune Polyglandular Syndrome Type 2
Diabetes Mellitus, Addison Disease, Myxedema	Polyglandular Autoimmune Syndrome, Type Ii
Pga Ii	Polyendocrine Autoimmune Syndrome, Type Ii
Aps Ii	Autoimmune Polyglandular Syndrome Type Ii
Diabetes Mellitus, Addison'S Disease, Myxedema	Multiple Endocrine Deficiency Syndrome, Type 2
Pga 2	Pga-Ii
Polyglandular Autoimmune Syndrome, Type 2	Polyglandular Deficiency Syndrome Type 2
Schmidt'S Syndrome	Autoimmune Polyendocrinopathy Type 2
Aps Type 2	Autoimmune Thyroid Disease And/Or Type 1 Diabetes-Addison Disease Syndrome
Autoimmune Syndrome Type Ii Polyglandular	Autoimmune Syndrome Type Ii, Polyglandular

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Bird Fancier'S Lung

Bird Fancier Lung	Pigeon Breeder'S Lung
Avian Hypersensitivity Pneumonitis	Bird Breeder'S Lung
Bird-Fancier'S Lung	Bird-Fanciers' Lung
Poultry Worker'S Lung	Pigeon-Breeder Lung Disease
Pigeon Breeders Lung	Avian Protein Hypersensitivity
Bird Breeders' Disease	Bird Breeders' Lung
Bird Fanciers' Lung	Bird Fanciers' Disease
Bfl - [Bird Fancier Lung]	Fanciers' Disease
Fanciers' Lung

Immunoglobulin A Deficiency 1

Immunoglobulin A Deficiency	Selective Iga Deficiency Disease
Selective Immunoglobulin A Deficiency	IGAD1
Immunoglobulin A, Selective Deficiency Of	Iga, Selective Deficiency Of
Gamma-A-Globulin, Selective Deficiency Of	Selective Iga Immunodeficiency
Selective Iga Deficiency	Iga Deficiency Selective

Robinow Syndrome, Autosomal Dominant 1

Autosomal Dominant Robinow Syndrome 1	DRS1
Robinow Dwarfism	Fetal Face Syndrome
Acral Dysostosis With Facial And Genital Abnormalities	Robinow, Autosomal Dominant Syndrome, Type 1

Parotid Disease

Parotid Diseases

Pernicious Anemia

Anemia, Pernicious	Anemia Pernicious
Pernicious Anaemia	Addison'S Anaemia
Biermer'S Anaemia	Biermer'S Anemia
Acquired Pernicious Anemia	Addison-Biermer Anemia
Addisonian Anemia	Biermer Anemia
Biermer'S Disease	Juvenile Onset Pernicious Anemia
Biermer Disease	Biermer-Addison Disease

Punctate Epithelial Keratoconjunctivitis

Punctate Keratitis	Thygeson Superficial Punctate Keratitis
Thygeson'S Superficial Punctate Keratitis	Thygeson Superficial Punctate Keratopathy
Punctate Epithelial Keratitis

Autoimmune Disease Of Gastrointestinal Tract

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Lymphocytic Colitis

Colitis, Lymphocytic

Type 1 Diabetes Mellitus 15

Diabetes Mellitus, Insulin-Dependent, 15	Iddm15
Insulin-Dependent Diabetes Mellitus 15	T1D15
Insulin-Dependent Diabetes Mellitus-15

Adrenal Cortex Disease

Adrenal Cortex Diseases

Lymphoid Interstitial Pneumonia

Lymphocytic Interstitial Pneumonia	Lip Disease
Lip Diseases	LIP
Disease Of Lips

Sclerosing Cholangitis

Fibrosing Cholangitis	Cholangitis, Sclerosing
Primary Sclerosing Cholangitis

Hashimoto Thyroiditis

Autoimmune Thyroiditis	Hashimoto Struma
Hashimoto'S Thyroiditis	Chronic Lymphocytic Thyroiditis
Lymphocytic Thyroiditis	Hashimoto Disease
Ht	Hashimoto'S Disease
Hashimoto'S Syndrome	Hypothyroidism, Autoimmune
Autoimmune Chronic Lymphocytic Thyroiditis	Chronic Lymphocytic Thyroiditides
Hashimoto Syndrome	Hashimotos Thyroiditis
Hashimoto Thyroiditis, Susceptibility To	Thyroiditis, Autoimmune
Lymphomatous Thyroiditis	Lymphoid Thyroiditis
Chronic Lymphadenoid Thyroiditis	Autoimmune Lymphocytic Chronic Thyroiditis
Goitre Lymphomatosa	Hashitoxicosis
Hashimoto Hypothyroidism	Lymphadenoid Goitre
Struma Lymphomatosa	Hyperthyroidism With Hashimoto Disease
Hashimoto Thyrotoxicosis	Thyrotoxicosis Due To Hashimoto Thyroiditis
Struma Lymphomatosis	Lymphadenoid Struma

Type 1 Diabetes Mellitus 12

Diabetes Mellitus, Insulin-Dependent, 12	IDDM12
Insulin-Dependent Diabetes Mellitus 12	T1D12
Type 1 Diabetes Mellitus 12, Susceptibility To	Diabetes Mellitus, Insulin-Dependent, Type 12

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Invasive Malignant Thymoma

Infiltrating Thymoma	Thymoma Malignant Invasive
Invasive Thymoma And Thymic Carcinoma

Diabetes Mellitus

Diabetes

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14813	TNFRSF25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TNFRSF25	MGD	MGI:1934667
Rattus norvegicus	TNFRSF25	RGD	RGD:1598206
Felis catus	TNFRSF25	VGNC	VGNC:66410
Macaca mulatta	TNFRSF25	VGNC	VGNC:78584
Canis familiaris	TNFRSF25	VGNC	VGNC:47664
Bos taurus	TNFRSF25	VGNC	VGNC:36167
Others	TNFRSF25	NCBI