IL18RAP - interleukin 18 receptor accessory protein Gene

Homo sapiens

Also known as ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta

Gene ID: 8807 | Gene type: protein coding

About IL18RAP

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:102,418,621-102,452,565 (from NCBI)

This gene has 5 transcripts (splice variants), 161 orthologues and 10 paralogues. Biased expression in bone marrow (RPKM 26.2), appendix (RPKM 5.0) and 4 other tissues.

Summary

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

IL18RAP Products(5)

mRNA	Protein	Name
NM_001393486.1	NP_001380415.1	interleukin-18 receptor accessory protein isoform 1 precursor
NM_001393487.1	NP_001380416.1	interleukin-18 receptor accessory protein isoform 1 precursor
NM_001393488.1	NP_001380417.1	interleukin-18 receptor accessory protein isoform 2
NM_001393489.1	NP_001380418.1	interleukin-18 receptor accessory protein isoform 2
NM_003853.4	NP_003844.1	interleukin-18 receptor accessory protein isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables coreceptor activity	IDA IDA: Inferred from direct assay	25500532	GOA
enables interleukin-18 receptor activity	IDA IDA: Inferred from direct assay	25500532	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in interleukin-18-mediated signaling pathway	IDA IDA: Inferred from direct assay	25500532	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	25500532	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of interleukin-18 receptor complex	IDA IDA: Inferred from direct assay	25500532	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL18RAP Protein Structure

Ig_2

TIR

0
100
200
300
400
500
599 a.a.

Protein Preferred Names

Protein Names

interleukin-18 receptor accessory protein

CD218 antigen-like family member B

IL18RAP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IL18RAP	O95256	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	IL18RAP	O95256	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	IL18RAP	O95256	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL18RAP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72573	IL-18R beta/IL-1R7 Protein, Human (HEK293, His)	O95256-1 (F20-R356)	≥95%
HY-P76425	IL-18R beta/IL-1R7 Protein, Human (HEK293, Fc)	O95256-1 (F20-G357)	≥95%

Related Diseases

Diseases

Alias

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Inflammatory Bowel Disease 5

IBD5

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06711	IL18RAP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IL18RAP	VGNC	VGNC:73715
Felis catus	IL18RAP	VGNC	VGNC:80121
Rattus norvegicus	IL18RAP	RGD	RGD:727867
Bos taurus	IL18RAP	VGNC	VGNC:30128
Canis familiaris	IL18RAP	VGNC	VGNC:41954
Mus musculus	IL18RAP	MGD	MGI:1338888
Others	IL18RAP	NCBI

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