CCKAR - cholecystokinin A receptor Gene

Homo sapiens

Also known as CCK-A; CCK1R; CCKRA; CCK1-R

Gene ID: 886 | Gene type: protein coding

About CCKAR

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:26,481,396-26,490,484 (from NCBI)

This gene has 1 transcript (splice variant), 202 orthologues and 16 paralogues. Biased expression in gall bladder (RPKM 17.2) and stomach (RPKM 6.8).

Summary

This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide Hormones. This receptor is a major physiologic mediator of pancreatic Enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]

CCKAR Products(1)

mRNA	Protein	Name
NM_000730.3	NP_000721.1	cholecystokinin receptor type A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cholecystokinin receptor activity	IDA IDA: Inferred from direct assay	8503909	GOA
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	8503909	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cholecystokinin signaling pathway	IDA IDA: Inferred from direct assay	8503909	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	8503909	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCKAR Protein Structure

CholecysA-Rec_N

7tm_1

0
100
200
300
400
428 a.a.

Protein Preferred Names

Protein Names

cholecystokinin receptor type A

CCK-A receptor	CCK-AR
cholecystokinin type-A receptor	cholecystokinin-1 receptor

Related Diseases

Diseases

Alias

Diabetes Mellitus

Diabetes

Gastroesophageal Reflux

Gastroesophageal Reflux Disease	Gerd
GER	Gastroesophageal Reflux, Pediatric
Acid Reflux	Gastresophageal Reflux
Gastro-Esophageal Reflux	Gerd - Gastro-Esophageal Reflux Disease

Exocrine Pancreatic Insufficiency

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Gastrointestinal System Disease

Gastrointestinal Disease	Gastrointestinal Diseases
Alimentary System Disease	Digestive System Disorder
Gastroenteropathy	Gastrointestinal Disorder
Git Disease	Digestive System Diseases
Gastrointestinal Disorders	Digestive System Disease
Digestive System Disorders

Cascade Stomach

Hourglass Stricture Or Stenosis Of Stomach	Hourglass Contraction Of Stomach
Hourglass Stenosis Of Stomach	Hourglass Stricture Of Stomach

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Cholecystitis

Acute Cholecystitis	Chronic Cholecystitis
Acalculous Cholecystitis	Acute And Chronic Cholecystitis
Acute On Chronic Cholecystitis	Gallstone Cholecystitis
Cholecystitis, Acute	Calculus Of Gallbladder With Cholecystitis
Gallbladder Inflammation	Acute Cholecystitis Infection
Acute Acalculous Cholecystitis	Chronic Acalculous Cholecystitis
Nonfunctioning Gallbladder

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Eating Disorder

Eating Disorders

Feeding And Eating Disorders

Pancreas Disease

Abnormality Of The Pancreas

Pancreatic Diseases

Functionless Pituitary Adenoma

Non-Functioning Neoplasm Of The Pituitary	Non-Secretory Adenoma Of The Pituitary Gland
Non-Functioning Pituitary Gland Neoplasm

Cholelithiasis

Cholecystolithiasis

Gallbladder Disease

Gallbladder Diseases	Gall Bladder
Gall Bladder Diseases	Abnormal Gallbladder Function

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1096	A71623	Agonist	99.90%	Unkown
HY-B2154	Loxiglumide	Antagonist	≥98.0%	Unkown
HY-129810	PD 135158	Antagonist	/	Unkown
HY-123434	PD-149164	Agonist	/	Unkown
HY-119127	TP-680	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CCKAR	RGD	RGD:2289
Canis familiaris	CCKAR	VGNC	VGNC:38879
Bos taurus	CCKAR	VGNC	VGNC:26941
Mus musculus	CCKAR	MGD	MGI:99478
Felis catus	CCKAR	VGNC	VGNC:60536
Macaca mulatta	CCKAR	VGNC	VGNC:106561

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