CPNE3 - copine 3 Gene

Homo sapiens

Also known as CPN3; PRO1071

Gene ID: 8895 | Gene type: protein coding

About CPNE3

Cytogenetic location: 8q21.3 Genomic coordinates (GRCh38): 8:86,514,435-86,561,498 (from NCBI)

This gene has 13 transcripts (splice variants), 208 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 40.1), esophagus (RPKM 38.1) and 25 other tissues.

Summary

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands. [provided by RefSeq, Aug 2008]

CPNE3 Products(1)

mRNA	Protein	Name
NM_003909.5	NP_003900.1	copine-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent phospholipid binding	IDA IDA: Inferred from direct assay	9430674	GOA
enables calcium-dependent protein binding	IDA IDA: Inferred from direct assay	20010870	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20010870	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11041869	GOA
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	20010870	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERBB2 signaling pathway	IDA IDA: Inferred from direct assay	20010870	GOA
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	20010870	GOA
involved in cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	20010870	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20010870	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell junction	IDA IDA: Inferred from direct assay	20010870	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20010870	GOA
located in cytosol	IDA IDA: Inferred from direct assay	12949241	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	20010870	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20010870	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20010870	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPNE3 Protein Structure

Copine

0
100
200
300
400
500
537 a.a.

Protein Preferred Names

Protein Names

copine-3

copine III

Related Diseases

Diseases

Alias

Bardet-Biedl Syndrome 2

BBS2	Bardet-Biedl Syndrome
Bardet-Biedl Syndrome, Type 2	Bbs

Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03105	CPNE3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CPNE3	MGD	MGI:1917818
Rattus norvegicus	CPNE3	RGD	RGD:1310178
Bos taurus	CPNE3	VGNC	VGNC:27660
Felis catus	CPNE3	VGNC	VGNC:61130
Canis familiaris	CPNE3	VGNC	VGNC:39562
Macaca mulatta	CPNE3	VGNC	VGNC:71465

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