AP1G2 - adaptor related protein complex 1 subunit gamma 2 Gene

Homo sapiens

Also known as G2AD

Gene ID: 8906 | Gene type: protein coding

About AP1G2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,559,567-23,567,791 (from NCBI)

This gene has 34 transcripts (splice variants), 186 orthologues and 4 paralogues. Ubiquitous expression in skin (RPKM 20.0), lymph node (RPKM 17.8) and 25 other tissues.

Summary

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. [provided by RefSeq, Aug 2017]

AP1G2 Products(8)

mRNA	Protein	Name
NM_001282474.2	NP_001269403.1	AP-1 complex subunit gamma-like 2 isoform 2
NM_001282475.2	NP_001269404.1	AP-1 complex subunit gamma-like 2 isoform 3
NM_001354673.2	NP_001341602.1	AP-1 complex subunit gamma-like 2 isoform 4
NM_001354674.2	NP_001341603.1	AP-1 complex subunit gamma-like 2 isoform 2
NM_001354675.2	NP_001341604.1	AP-1 complex subunit gamma-like 2 isoform 2
NM_001354677.2	NP_001341606.1	AP-1 complex subunit gamma-like 2 isoform 2
NM_001354681.2	NP_001341610.1	AP-1 complex subunit gamma-like 2 isoform 2
NM_003917.5	NP_003908.1	AP-1 complex subunit gamma-like 2 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12505986	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi-associated vesicle	IDA IDA: Inferred from direct assay	9762922	GOA
located in membrane	IDA IDA: Inferred from direct assay	9733768	GOA
located in transport vesicle	IDA IDA: Inferred from direct assay	9733768	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AP1G2 Protein Structure

Adaptin_N

Alpha_adaptinC2

0
200
400
600
785 a.a.

Protein Preferred Names

Protein Names

AP-1 complex subunit gamma-like 2

adaptor related protein complex 1 gamma 2 subunit

Related Diseases

Diseases

Alias

Tracheoesophageal Fistula With Or Without Esophageal Atresia

Esophageal Atresia With Or Without Tracheoesophageal Fistula

Esophageal Atresia

Tracheoesophageal Fistula	Congenital Atresia Of Esophagus
Congenital Imperforate Esophagus	Imperforate Esophagus
Oesophageal Atresia	Te Fistula
Tef	Tracheoesophageal Fistula With Or Without Esophageal Atresia

Intellectual Developmental Disorder, Autosomal Dominant 56

Mental Retardation, Autosomal Dominant 56	MRD56
Autosomal Dominant Mental Retardation 56	Autosomal Dominant Intellectual Developmental Disorder 56
Autosomal Dominant Intellectual Developmental Disorder-56

Developmental And Epileptic Encephalopathy 48

DEE48	Epileptic Encephalopathy, Early Infantile, 48
Eiee48	Developmental And Epileptic Encephalopathy, 48
Early Infantile Epileptic Encephalopathy 48

Psoriasis 15

Psors15

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00778	AP1G2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	AP1G2	VGNC	VGNC:69959
Felis catus	AP1G2	VGNC	VGNC:81040
Canis familiaris	AP1G2	VGNC	VGNC:37953
Bos taurus	AP1G2	VGNC	VGNC:25978
Mus musculus	AP1G2	MGD	MGI:1328307
Rattus norvegicus	AP1G2	RGD	RGD:2324507

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