ENDOU - endonuclease, poly(U) specific Gene

Homo sapiens

Also known as P11; PP11; PRSS26

Gene ID: 8909 | Gene type: protein coding

About ENDOU

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:47,709,734-47,725,490 (from NCBI)

This gene has 4 transcripts (splice variants) and 211 orthologues. Biased expression in esophagus (RPKM 34.0), skin (RPKM 9.4) and 1 other tissue.

Summary

This gene encodes a protein with endoribonuclease activity that binds polyuridine-enriched single-stranded RNA. This gene was initially characterized based on its high expression in placenta but was mischaracterized as a serine protease. In mouse, this gene promotes tolerance to self-antigens by regulating B cell activation-induced cell death (AICD). The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2020]

ENDOU Products(3)

mRNA	Protein	Name
NM_001172439.2	NP_001165910.1	uridylate-specific endoribonuclease isoform 1 precursor
NM_001172440.2	NP_001165911.1	uridylate-specific endoribonuclease isoform 3 precursor
NM_006025.4	NP_006016.1	uridylate-specific endoribonuclease isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	18936097	GOA
enables RNA endonuclease activity	IDA IDA: Inferred from direct assay	18936097	GOA
enables RNA endonuclease activity	IGI IGI: Inferred from genetic interaction	37803019	GOA
NOT enables serine-type peptidase activity	IDA IDA: Inferred from direct assay	18936097	GOA
enables serine-type peptidase activity	IDA IDA: Inferred from direct assay	2350438	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in female pregnancy	IEP IEP: Inferred from expression pattern	2350438	GOA
involved in negative regulation of lipid catabolic process	IGI IGI: Inferred from genetic interaction	37803019	GOA
involved in post-transcriptional gene silencing	IGI IGI: Inferred from genetic interaction	37803019	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	2350438	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	6755403	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENDOU Protein Structure

Somatomedin_B

XendoU

0
100
200
300
410 a.a.

Protein Preferred Names

Protein Names

uridylate-specific endoribonuclease

22 serine protease

Related Diseases

Diseases

Alias

Rapp-Hodgkin Syndrome

RHS	Anhidrotic Ectodermal Dysplasia With Cleft Lip/Palate
Ectodermal Dysplasia, Rapp-Hodgkin Type	Rapp-Hodgkin Ectodermal Dysplasia Syndrome
Ectodermal Dysplasia, Anhidrotic, With Cleft Lip/Palate	Ectodermal Dysplasia Syndrome, Rapp-Hodgkin Type
Edrh	Rapp-Hodgkin Ectodermal Dysplasia
Orofacial Cleft 8

Noonan Syndrome 6

NS6	Noonan Syndrome, Type 6

Non-Gestational Choriocarcinoma

Choriocarcinoma, Non-Gestational

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04372	ENDOU Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ENDOU	VGNC	VGNC:83873
Macaca mulatta	ENDOU	VGNC	VGNC:99925
Rattus norvegicus	ENDOU	RGD	RGD:1593011
Mus musculus	ENDOU	MGD	MGI:97746

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