KYNU - kynureninase Gene

Homo sapiens

Also known as KYNUU; VCRL2

Gene ID: 8942 | Gene type: protein coding

About KYNU

Cytogenetic location: 2q22.2 Genomic coordinates (GRCh38): 2:142,877,664-143,055,833 (from NCBI)

This gene has 9 transcripts (splice variants), 224 orthologues and is associated with 4 phenotypes. Broad expression in liver (RPKM 2.5), urinary bladder (RPKM 1.8) and 14 other tissues.

Summary

Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent Enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

KYNU Products(3)

mRNA	Protein	Name
NM_001032998.2	NP_001028170.1	kynureninase isoform b
NM_001199241.2	NP_001186170.1	kynureninase isoform a
NM_003937.3	NP_003928.1	kynureninase isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kynureninase activity	IDA IDA: Inferred from direct assay	9180257	GOA
enables kynureninase activity	IMP IMP: Inferred from mutant phenotype	17334708	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11985583	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in NAD biosynthetic process	IMP IMP: Inferred from mutant phenotype	28792876	GOA
involved in anthranilate metabolic process	IDA IDA: Inferred from direct assay	11985583	GOA
involved in quinolinate biosynthetic process	IDA IDA: Inferred from direct assay	9291104	GOA
involved in response to type II interferon	IDA IDA: Inferred from direct assay	9291104	GOA
involved in response to vitamin B6	IMP IMP: Inferred from mutant phenotype	1939450	GOA
involved in tryptophan catabolic process	IMP IMP: Inferred from mutant phenotype	17334708	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	6468727	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	6468727	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KYNU Protein Structure

Aminotran_5

0
100
200
300
400
465 a.a.

Protein Preferred Names

Protein Names

kynureninase

Recombinant KYNU Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75903	KYNU/Kynureninase Protein, Human (sf9, His)	Q16719 (M1-N465)	≥95%

Related Diseases

Diseases

Alias

Hydroxykynureninuria

Xanthurenic Aciduria	Kynureninase Deficiency
Kynureninase Deficiency, Partial	HYXKY
Partial Kynureninase Deficiency

Vertebral, Cardiac, Renal, And Limb Defects Syndrome 2

VCRL2	Congenital Nad Deficiency Disorder 2
Kynureninase Deficiency, Complete

Congenital Vertebral-Cardiac-Renal Anomalies Syndrome

Congenital Nad Deficiency Disorder

Catel-Manzke Syndrome

Hyperphalangy-Clinodactyly Of Index Finger With Pierre Robin Syndrome	Micrognathia Digital Syndrome
Pierre Robin Syndrome With Hyperphalangy And Clinodactyly	Index Finger Anomaly With Pierre Robin Syndrome
Palatodigital Syndrome, Catel-Manzke Type	Catel Manzke Syndrome
CATMANS	Palatodigital Syndrome Catel-Manzke Type
Index Finger Anomaly-Pierre Robin Syndrome	Pierre Robin Sequence-Hyperphalangy-Clinodactyly Syndrome
Pierre Robin Syndrome-Hyperphalangy-Clinodactyly Syndrome

Transient Cerebral Ischemia

Transient Ischemic Attack	Transient Ischemic Attacks
Tia	Tia - Transient Ischaemic Attack
Transient Cerebral Ischaemia	Ischemic Attack, Transient
Intermittent Cerebral Ischemia	Tia - [Transient Ischaemic Attack]
Intermittent Cerebral Ischaemia	Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified

Pellagra

Niacin Deficiency	Niacin-Tryptophan Deficiency
Pellagroid Syndrome

Meier-Gorlin Syndrome 2

MGORS2

Meier-Gorlin Syndrome, Type 2

Epilepsy, Idiopathic Generalized 9

Epilepsy, Idiopathic Generalized, Susceptibility To, 9	EIG9
Epilepsy, Juvenile Myoclonic 6	Idiopathic Generalized Epilepsy 9
Epilepsy, Juvenile Myoclonic, Susceptibility To, 6	Susceptibility To Idiopathic Generalized Epilepsy 9
Juvenile Myoclonic Epilepsy 6	EJM6
Susceptibility To Juvenile Myoclonic Epilepsy 6	Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 9

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07480	KYNU Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KYNU	VGNC	VGNC:30759
Felis catus	KYNU	VGNC	VGNC:67998
Mus musculus	KYNU	MGD	MGI:1918039
Rattus norvegicus	KYNU	RGD	RGD:71061
Canis familiaris	KYNU	VGNC	VGNC:42555
Macaca mulatta	KYNU	VGNC	VGNC:74223
Others	KYNU	NCBI

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