2. Gene
  3. USP13 - ubiquitin specific peptidase 13 Gene

USP13 - ubiquitin specific peptidase 13 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ISOT3; IsoT-3

Gene ID: 8975 | Gene type: protein coding

About USP13

Cytogenetic location: 3q26.33 Genomic coordinates (GRCh38): 3:179,653,040-179,789,401 (from NCBI)

This gene has 73 transcripts (splice variants), 207 orthologues and 71 paralogues. Broad expression in heart (RPKM 16.6), adrenal (RPKM 7.5) and 21 other tissues.

Summary

Enables several functions, including BAT3 complex binding activity; chaperone binding activity; and cysteine-type peptidase activity. Involved in several processes, including maintenance of unfolded protein involved in ERAD pathway; regulation of cellular catabolic process; and regulation of transcription, DNA-templated. Acts upstream of or within protein deubiquitination and protein stabilization. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

USP13 Products(1)

mRNA Protein Name
NM_003940.3 NP_003931.2 ubiquitin carboxyl-terminal hydrolase 13

USP13 Protein Structure

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (211 - 283)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (335 - 858)

UBA

UBA: UBA/TS-N domain (653 - 690)

UBA

UBA: UBA/TS-N domain (729 - 764)

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  • 863 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 13

deubiquitinating enzyme 13

Related Diseases

Diseases Alias
Fetal Adenoma

Microfollicular Adenoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12990 Spautin-1 99.27% Unkown
HY-RS15524 USP13 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris USP13 VGNC VGNC:49638
Macaca mulatta USP13 VGNC VGNC:78735
Felis catus USP13 VGNC VGNC:66867
Rattus norvegicus USP13 RGD RGD:1306044
Bos taurus USP13 VGNC VGNC:52841
Mus musculus USP13 MGD MGI:1919857