USP13 - ubiquitin specific peptidase 13 Gene

Homo sapiens

Also known as ISOT3; IsoT-3

Gene ID: 8975 | Gene type: protein coding

About USP13

Cytogenetic location: 3q26.33 Genomic coordinates (GRCh38): 3:179,653,040-179,789,401 (from NCBI)

This gene has 73 transcripts (splice variants), 207 orthologues and 71 paralogues. Broad expression in heart (RPKM 16.6), adrenal (RPKM 7.5) and 21 other tissues.

Summary

Enables several functions, including BAT3 complex binding activity; chaperone binding activity; and cysteine-type peptidase activity. Involved in several processes, including maintenance of unfolded protein involved in ERAD pathway; regulation of cellular catabolic process; and regulation of transcription, DNA-templated. Acts upstream of or within protein deubiquitination and protein stabilization. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

USP13 Products(1)

mRNA	Protein	Name
NM_003940.3	NP_003931.2	ubiquitin carboxyl-terminal hydrolase 13

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables BAT3 complex binding	IDA IDA: Inferred from direct assay	24424410	GOA
enables K48-linked deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	24424410	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	21811243	GOA
enables cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	21811243	GOA
enables proteasome binding	IDA IDA: Inferred from direct assay	24424410	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21811243	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	24424410	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	21659512	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	21659512	GOA
enables ubiquitin-like protein ligase binding	IPI IPI: Inferred from physical interaction	24424410	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	21811243	GOA
involved in maintenance of unfolded protein	IMP IMP: Inferred from mutant phenotype	24424410	GOA
involved in positive regulation of ERAD pathway	IMP IMP: Inferred from mutant phenotype	24424410	GOA
acts upstream of or within protein K29-linked deubiquitination	IDA IDA: Inferred from direct assay	26280536	GOA
acts upstream of or within protein K6-linked deubiquitination	IDA IDA: Inferred from direct assay	26280536	GOA
acts upstream of or within protein K63-linked deubiquitination	IDA IDA: Inferred from direct assay	26280536	GOA
involved in protein K63-linked deubiquitination	IDA IDA: Inferred from direct assay	22216260	GOA
acts upstream of or within protein stabilization	IDA IDA: Inferred from direct assay	26280536	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	21659512	GOA
acts upstream of or within protein stabilization	IMP IMP: Inferred from mutant phenotype	26280536	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	21811243	GOA
involved in regulation of autophagy	IDA IDA: Inferred from direct assay	21962518	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP13 Protein Structure

zf-UBP

UCH

UBA

0
200
400
600
800
863 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 13

deubiquitinating enzyme 13

USP13 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	USP13	Q92995	P0DTD1-PRO_0000449630	SARS-CoV-2	P0DTD1-PRO_0000449630	Anti Tag CoIP	33707416

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Fetal Adenoma

Microfollicular Adenoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12990	Spautin-1		99.27%	Unkown
HY-RS15524	USP13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	USP13	VGNC	VGNC:49638
Macaca mulatta	USP13	VGNC	VGNC:78735
Felis catus	USP13	VGNC	VGNC:66867
Rattus norvegicus	USP13	RGD	RGD:1306044
Bos taurus	USP13	VGNC	VGNC:52841
Mus musculus	USP13	MGD	MGI:1919857

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