2. Gene
  3. SIGLEC10 - sialic acid binding Ig like lectin 10 Gene

SIGLEC10 - sialic acid binding Ig like lectin 10 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SLG2; PRO940; SIGLEC-10

Gene ID: 89790 | Gene type: protein coding

About SIGLEC10

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,410,020-51,417,642 (from NCBI)

This gene has 11 transcripts (splice variants), 124 orthologues and 16 paralogues. Biased expression in appendix (RPKM 14.2), spleen (RPKM 13.0) and 12 other tissues.

Summary

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]

SIGLEC10 Products(7)

mRNA Protein Name
NM_001171156.2 NP_001164627.1 sialic acid-binding Ig-like lectin 10 isoform 2 precursor
NM_001171157.2 NP_001164628.1 sialic acid-binding Ig-like lectin 10 isoform 3 precursor
NM_001171158.2 NP_001164629.1 sialic acid-binding Ig-like lectin 10 isoform 4 precursor
NM_001171159.2 NP_001164630.1 sialic acid-binding Ig-like lectin 10 isoform 5 precursor
NM_001171161.2 NP_001164632.1 sialic acid-binding Ig-like lectin 10 isoform 7 precursor
NM_001322105.2 NP_001309034.1 sialic acid-binding Ig-like lectin 10 isoform 8 precursor
NM_033130.5 NP_149121.2 sialic acid-binding Ig-like lectin 10 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SH2 domain binding IMP
IMP: Inferred from mutant phenotype
12163025 GOA
enables phosphatase binding IPI
IPI: Inferred from physical interaction
12163025 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19264983 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of inflammatory response to wounding IPI
IPI: Inferred from physical interaction
19264983 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
11284738 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIGLEC10 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (26 - 129)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (147 - 223)

I-set

I-set: Immunoglobulin I-set domain (264 - 340)

Ig_2

Ig_2: Immunoglobulin domain (369 - 442)

  • 0
  • 200
  • 400
  • 600
  • 697 a.a.
Protein Preferred Names Protein Names

sialic acid-binding Ig-like lectin 10

sialic acid binding Ig-like lectin 10 Ig-like lectin 7

Recombinant SIGLEC10 Proteins

Cat. No. Product Name Accession Purity
HY-P72411 Siglec-10 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q96LC7-1 (M17-T546) ≥95%
HY-P72476 Siglec-10 Protein, Human (HEK293, Fc) Q96LC7-1 (M17-T546) ≥95%
HY-P76642 Siglec-10 Protein, Human (HEK293, His) AAI01726.1 (M17-N550) ≥95%
HY-P78205 Siglec-10 Protein, Human (Biotinylated, HEK293, His-Avi) Q96LC7-1 (M17-T546) ≥95%
HY-P78206 Siglec-10 Protein, Human (Biotinylated, R119A, HEK293, His-Avi) Q96LC7-1 (M17-T546, R119A) ≥95%
HY-P78514 Siglec-10 Protein, Human (R119A, HEK293, His-Avi) Q96LC7-1 (M17-T546, R119A) ≥95%
HY-P78516 Siglec-10 Protein, Human (HEK293, Fc-Avi) Q96LC7-1 (M17-T546) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P10091 CD24/Siglec-10 blocking peptide, CSBP Inhibitor 99.59% Unkown
HY-RS12898 SIGLEC10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SIGLEC10 VGNC VGNC:77237
Rattus norvegicus SIGLEC10 RGD RGD:1307441
Mus musculus SIGLEC10 MGD MGI:2443630
Macaca fascicularis SIGLEC10 NCBI NCBI:102125591
Others SIGLEC10 NCBI