PGLYRP1 - peptidoglycan recognition protein 1 Gene

Homo sapiens

Also known as PGRP; TAG7; PGRPS; PGLYRP; PGRP-S; TNFSF3L

Gene ID: 8993 | Gene type: protein coding

About PGLYRP1

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,019,153-46,023,053 (from NCBI)

This gene has 1 transcript (splice variant), 184 orthologues and 3 paralogues. Restricted expression toward bone marrow (RPKM 135.5).

Summary

Enables peptidoglycan binding activity and peptidoglycan immune receptor activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of Other organism; and response to bacterium. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

PGLYRP1 Products(1)

mRNA	Protein	Name
NM_005091.3	NP_005082.1	peptidoglycan recognition protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp70 protein binding	IDA IDA: Inferred from direct assay	14585845	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	26654597	GOA
enables peptidoglycan binding	IDA IDA: Inferred from direct assay	11461926	GOA
enables peptidoglycan immune receptor activity	IDA IDA: Inferred from direct assay	11461926	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	25595774	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	16354652	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	11461926	GOA
involved in detection of bacterium	IDA IDA: Inferred from direct assay	11461926	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	16354652	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	14585845	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGLYRP1 Protein Structure

Amidase_2

0
100
196 a.a.

Protein Preferred Names

Protein Names

peptidoglycan recognition protein 1

TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein)

Recombinant PGLYRP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78014	PGLYRP1/PGRP-S Protein, Human (HEK293, Fc)	O75594 (Q22-P196)	≥95%

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 86

RP86	Retinitis Pigmentosa, Type 86

Immunodeficiency 60

Bach2-Related Immunodeficiency And Autoimmunity	Brida
Imd60

Psoriasis 4

PSORS4	Psoriasis Susceptibility 4
Psoriasis 4, Susceptibility To

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Mite Infestation

Mite Infestations	Acariasis
Infestation By Mites Nos

Trombiculiasis

Parasitic Ectoparasitic Infectious Disease

Ectoparasitic Infestations

Ectoparasitism

Trench Fever

His-Werner Disease	Quintan Fever
Shin Bone Fever	Wolhynian Fever
Tibialgic Fever	Bartonellosis Due To Bartonella Quintana Infection
Febris Quintata	Five Day Fever
Fever Due To Rickettsia Quintana	Febris Quintana
Fever Due To Bartonella Quintana	Fever Due To Rochalimaea Quintana
Meuse Fever

Cicatricial Entropion

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10387	PGLYRP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PGLYRP1	MGD	MGI:1345092
Macaca mulatta	PGLYRP1	VGNC	VGNC:75968
Bos taurus	PGLYRP1	VGNC	VGNC:32791
Rattus norvegicus	PGLYRP1	RGD	RGD:621429
Felis catus	PGLYRP1	VGNC	VGNC:68817
Canis familiaris	PGLYRP1	VGNC	VGNC:44461
Others	PGLYRP1	NCBI

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