PGLYRP1/PGRP-S Protein, Human (HEK293, Fc)

The PGLYRP1/PGRP-S protein is critical to the innate immune system and serves as a model receptor that binds to Gram-positive bacterial PGN to exert bactericidal activity. It forms a complex with HSPA1A and induces programmed cell death in tumor cells. PGLYRP1/PGRP-S Protein, Human (HEK293, Fc) is the recombinant human-derived PGLYRP1/PGRP-S protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PGLYRP1/PGRP-S Protein, Human (HEK293, Fc) is 175 a.a., with molecular weight of 50-65 kDa.

PGLYRP1/PGRP-S protein, an integral component of the innate immune system, serves crucial roles in antimicrobial and antitumor defense mechanisms. Functioning as a pattern receptor, it binds to murein peptidoglycans (PGN) from Gram-positive bacteria, exerting bactericidal activity. Furthermore, PGLYRP1 forms an equimolar complex with heat shock protein HSPA1A, inducing programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor. Acting in conjunction with the Ca(2+)-binding protein S100A4, it acts as a chemoattractant, capable of inducing lymphocyte movement by interacting with chemotactic receptors CCR5 and CXCR3 on immune system cells. This complex also promotes the activation of lymphocytes, enhancing their ability to eliminate virus-infected and tumor cells. The induction of cytotoxicity on monocyte surfaces requires interaction with the TREM1 receptor. PGLYRP1 forms homodimers through disulfide linkages and interacts with various proteins such as HSPBP1, TNFRSF1A, S100A4, and TREM1, orchestrating a network of interactions crucial for its diverse functions.

Immobilized Human TREM1, His Tag at 5 μg/mL (100 μl/well) on the plate. Dose response curve for Human PGLYRP1, hFc Tag with the EC₅₀ of ≤0.32 μg/mL determined by ELISA.

Human

HEK293

C-hFc

O75594 (Q22-P196)

8993  [NCBI]

50-65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.