LIMD1 - LIM domain containing 1 Gene

Homo sapiens

Gene ID: 8994 | Gene type: protein coding

About LIMD1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:45,594,751-45,686,341 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in lung (RPKM 16.2), thyroid (RPKM 9.3) and 25 other tissues.

Summary

Predicted to enable transcription corepressor activity. Involved in several processes, including negative regulation of hippo signaling; regulation of gene expression; and response to hypoxia. Acts upstream of or within P-body assembly and gene silencing by miRNA. Located in several cellular components, including P-body; adherens junction; and focal adhesion. Part of RISC complex. [provided by Alliance of Genome Resources, Apr 2022]

LIMD1 Products(1)

mRNA	Protein	Name
NM_014240.3	NP_055055.1	LIM domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15542589	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within P-body assembly	IMP IMP: Inferred from mutant phenotype	20616046	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in miRNA-mediated gene silencing by inhibition of translation	IMP IMP: Inferred from mutant phenotype	20616046	GOA
acts upstream of or within miRNA-mediated post-transcriptional gene silencing	IMP IMP: Inferred from mutant phenotype	20616046	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15542589	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	22286099	GOA
involved in negative regulation of hippo signaling	IDA IDA: Inferred from direct assay	20303269	GOA
involved in phosphorylation	IDA IDA: Inferred from direct assay	18439753	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	22286099	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	20616046	GOA
part of RISC complex	IDA IDA: Inferred from direct assay	20616046	GOA
located in adherens junction	IDA IDA: Inferred from direct assay	20303269	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15542589	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	18439753	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15542589	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIMD1 Protein Structure

LIM

0
200
400
600
676 a.a.

Protein Preferred Names

Protein Names

LIM domain-containing protein 1

LIM domains containing 1

LIMD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LIMD1	Q9UGP4	AGO2	Homo sapiens	Q9UKV8	Anti Bait CoIP	28683311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07659	LIMD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LIMD1	VGNC	VGNC:30888
Macaca mulatta	LIMD1	VGNC	VGNC:74268
Mus musculus	LIMD1	MGD	MGI:1352502
Rattus norvegicus	LIMD1	RGD	RGD:1309830
Canis familiaris	LIMD1	VGNC	VGNC:42679
Felis catus	LIMD1	VGNC	VGNC:68052

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