LACRT - lacritin Gene

Homo sapiens

Gene ID: 90070 | Gene type: protein coding

About LACRT

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:54,630,811-54,634,895 (from NCBI)

This gene has 4 transcripts (splice variants), 18 orthologues and 1 paralogue. Restricted expression toward salivary gland (RPKM 2.0).

Summary

The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. [provided by RefSeq, Jul 2008]

LACRT Products(1)

mRNA	Protein	Name
NM_033277.2	NP_150593.1	extracellular glycoprotein lacritin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables collagen binding	IDA IDA: Inferred from direct assay	11419941	GOA
enables growth factor activity	IDA IDA: Inferred from direct assay	16982797	GOA
enables laminin-1 binding	IDA IDA: Inferred from direct assay	11419941	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11419941	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcineurin-NFAT signaling cascade	IDA IDA: Inferred from direct assay	16923831	GOA
involved in calcium-mediated signaling	IDA IDA: Inferred from direct assay	11419941	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	24942736	GOA
involved in epithelial structure maintenance	IDA IDA: Inferred from direct assay	25034600	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	26670139	GOA
involved in negative regulation of lipopolysaccharide-mediated signaling pathway	IDA IDA: Inferred from direct assay	26670139	GOA
involved in positive regulation of calcineurin-NFAT signaling cascade	IDA IDA: Inferred from direct assay	16923831	GOA
involved in positive regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	25530855	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11419941	GOA
involved in positive regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	16923831	GOA
involved in positive regulation of epithelial cell proliferation involved in wound healing	IDA IDA: Inferred from direct assay	25530855	GOA
involved in positive regulation of macroautophagy	IDA IDA: Inferred from direct assay	23640897	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	11419941	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	16923831	GOA
involved in positive regulation of secretion	IDA IDA: Inferred from direct assay	11419941	GOA
involved in protein localization to Golgi apparatus	IDA IDA: Inferred from direct assay	16923831	GOA
involved in tear secretion	IDA IDA: Inferred from direct assay	25034600	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	17850790	GOA
located in secretory granule	IDA IDA: Inferred from direct assay	11419941	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

extracellular glycoprotein lacritin

Recombinant LACRT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70911	Lacritin Protein, Human (His)	Q9GZZ8 (A19-A138)	≥95%

Related Diseases

Diseases

Alias

Blepharitis

Chronic Follicular Conjunctivitis

Apperceptive Agnosia

Lacrimal Apparatus Disease

Lacrimal Apparatus Diseases

Eyelid Disease

Eyelid Diseases

Eyelid Disorders

Cicatricial Entropion

Keratopathy

Dry Eye Syndrome

Dry Eye Syndromes	Dry Eye Disease
Tear Film Insufficiency	Xerophthalmia

Conjunctivochalasis

Filamentary Keratitis

Orbital Cellulitis

Cellulitis Of Orbit

Acute Orbital Inflammation

Acute Inflammation Of Orbit

Papillary Conjunctivitis

Accommodative Spasm

Spasm Of Accommodation	Cyclospasm
Ciliary Muscle Spasm	Ciliary Body Spasm

Giant Papillary Conjunctivitis

Gpc	Conjunctivitis Giant Papillary
Conjunctivitis, Giant Papillary	Chronic Giant Papillary Conjunctivitis
Chronic Papillary Conjunctivitis

Exposure Keratitis

Exposure Keratoconjunctivitis

Lagophthalmic Keratitis

Entropion

Punctate Epithelial Keratoconjunctivitis

Punctate Keratitis	Thygeson Superficial Punctate Keratitis
Thygeson'S Superficial Punctate Keratitis	Thygeson Superficial Punctate Keratopathy
Punctate Epithelial Keratitis

Excessive Tearing

Epiphora	Lacrimal Apparatus Diseases
Excessive Tear Production	Watering Eye

Corneal Disease

Corneal Diseases

Corneal Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07488	LACRT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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