BRSK2 - BR serine/threonine kinase 2 Gene

Homo sapiens

Also known as SAD1; SADA; SAD-A; STK29; PEN11B; C11orf7

Gene ID: 9024 | Gene type: protein coding

About BRSK2

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,389,934-1,462,689 (from NCBI)

This gene has 15 transcripts (splice variants), 308 orthologues, 17 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 8.8), pancreas (RPKM 3.6) and 2 other tissues.

Summary

Enables several functions, including ATP binding activity; ATPase binding activity; and protein kinase activity. Involved in several processes, including cellular protein metabolic process; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and regulation of Insulin secretion involved in cellular response to glucose stimulus. Located in centrosome and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

BRSK2 Products(5)

mRNA	Protein	Name
NM_001256627.2	NP_001243556.1	serine/threonine-protein kinase BRSK2 isoform 1
NM_001256629.2	NP_001243558.1	serine/threonine-protein kinase BRSK2 isoform 3
NM_001256630.1	NP_001243559.1	serine/threonine-protein kinase BRSK2 isoform 4
NM_001282218.2	NP_001269147.1	serine/threonine-protein kinase BRSK2 isoform 5
NM_003957.4	NP_003948.2	serine/threonine-protein kinase BRSK2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	14976552	GOA
enables ATPase binding	IDA IDA: Inferred from direct assay	23907667	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	14976552	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22609399	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	14976552	GOA
enables tau-protein kinase activity	IDA IDA: Inferred from direct assay	21985311	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	23907667	GOA
involved in G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	23029325	GOA
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	22669945	GOA
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	22713462	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	14976552	GOA
involved in regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	22669945	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	23029325	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22713462	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23907667	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRSK2 Protein Structure

Pkinase

0
200
400
600
736 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase BRSK2

BR serine/threonine-protein kinase 2

Related Diseases

Diseases

Alias

Autosomal Dominant Non-Syndromic Intellectual Disability

Carrion'S Disease

Oroya Fever	Carrion Disease
Bartonellosis Due To Bartonella Bacilliformis Infection	Bartonella Infections
Systemic Bartonellosis Due To Bartonella Bacilliformis	Systemic Carrión Disease
Systemic Bartonellosis	Bartonella Fever

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Phase
HY-18174	Prexasertib	98.74%	Phase 2
HY-18174A	Prexasertib dihydrochloride	99.41%	Phase 2
HY-18174E	Prexasertib dimesylate	99.04%	Phase 2
HY-18174B	Prexasertib Mesylate Hydrate	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18174C	Prexasertib mesylate		/	Unkown
HY-RS01638	BRSK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-18174H	Prexasertib lactate		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BRSK2	VGNC	VGNC:70291
Felis catus	BRSK2	VGNC	VGNC:60185
Bos taurus	BRSK2	VGNC	VGNC:56257
Rattus norvegicus	BRSK2	RGD	RGD:1566256
Mus musculus	BRSK2	MGD	MGI:1923020
Canis familiaris	BRSK2	VGNC	VGNC:51843
Others	BRSK2	NCBI

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