2. Gene
  3. BRSK2 - BR serine/threonine kinase 2 Gene

BRSK2 - BR serine/threonine kinase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SAD1; SADA; SAD-A; STK29; PEN11B; C11orf7

Gene ID: 9024 | Gene type: protein coding

About BRSK2

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,389,934-1,462,689 (from NCBI)

This gene has 15 transcripts (splice variants), 308 orthologues, 17 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 8.8), pancreas (RPKM 3.6) and 2 other tissues.

Summary

Enables several functions, including ATP binding activity; ATPase binding activity; and protein kinase activity. Involved in several processes, including cellular protein metabolic process; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and regulation of Insulin secretion involved in cellular response to glucose stimulus. Located in centrosome and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

BRSK2 Products(5)

mRNA Protein Name
NM_001256627.2 NP_001243556.1 serine/threonine-protein kinase BRSK2 isoform 1
NM_001256629.2 NP_001243558.1 serine/threonine-protein kinase BRSK2 isoform 3
NM_001256630.1 NP_001243559.1 serine/threonine-protein kinase BRSK2 isoform 4
NM_001282218.2 NP_001269147.1 serine/threonine-protein kinase BRSK2 isoform 5
NM_003957.4 NP_003948.2 serine/threonine-protein kinase BRSK2 isoform 2

BRSK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (19 - 269)

  • 0
  • 200
  • 400
  • 600
  • 736 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase BRSK2

BR serine/threonine-protein kinase 2

Related Diseases

Diseases Alias
Autosomal Dominant Non-Syndromic Intellectual Disability
Carrion'S Disease

Oroya Fever

Carrion Disease

Bartonellosis Due To Bartonella Bacilliformis Infection

Bartonella Infections

Systemic Bartonellosis Due To Bartonella Bacilliformis

Systemic Carrión Disease

Systemic Bartonellosis

Bartonella Fever
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-18174 Prexasertib 98.74% Phase 2
HY-18174A Prexasertib dihydrochloride 99.41% Phase 2
HY-18174E Prexasertib dimesylate 99.04% Phase 2
HY-18174B Prexasertib Mesylate Hydrate / Phase 2
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18174C Prexasertib mesylate / Unkown
HY-RS01638 BRSK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-18174H Prexasertib lactate / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BRSK2 VGNC VGNC:70291
Felis catus BRSK2 VGNC VGNC:60185
Bos taurus BRSK2 VGNC VGNC:56257
Rattus norvegicus BRSK2 RGD RGD:1566256
Mus musculus BRSK2 MGD MGI:1923020
Canis familiaris BRSK2 VGNC VGNC:51843
Others BRSK2 NCBI