2. Gene
  3. TM4SF5 - transmembrane 4 L six family member 5 Gene

TM4SF5 - transmembrane 4 L six family member 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 9032 | Gene type: protein coding

About TM4SF5

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,771,886-4,783,211 (from NCBI)

This gene has 2 transcripts (splice variants), 188 orthologues and 5 paralogues. Biased expression in duodenum (RPKM 71.1), small intestine (RPKM 65.8) and 4 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008]

TM4SF5 Products(1)

mRNA Protein Name
NM_003963.3 NP_003954.2 transmembrane 4 L6 family member 5 precursor

TM4SF5 Protein Structure

L6_membrane

L6_membrane: L6 membrane protein (1 - 191)

  • 0
  • 100
  • 197 a.a.
Protein Preferred Names Protein Names

transmembrane 4 L6 family member 5

tetraspan transmembrane protein L6H

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14610 TM4SF5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TM4SF5 RGD RGD:1308709
Bos taurus TM4SF5 VGNC VGNC:35907
Macaca mulatta TM4SF5 VGNC VGNC:99301
Mus musculus TM4SF5 MGD MGI:1922854
Felis catus TM4SF5 VGNC VGNC:99559
Canis familiaris TM4SF5 VGNC VGNC:47410