2. Gene
  3. AMIGO1 - adhesion molecule with Ig like domain 1 Gene

AMIGO1 - adhesion molecule with Ig like domain 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ALI2; AMIGO; AMIGO-1

Gene ID: 57463 | Gene type: protein coding

About AMIGO1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,504,178-109,509,727 (from NCBI)

This gene has 2 transcripts (splice variants), 248 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 9.3), adrenal (RPKM 6.7) and 24 other tissues.

Summary

Predicted to enable Potassium Channel regulator activity. Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and nervous system development. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in dendrite and neuronal cell body membrane. Predicted to be integral component of membrane. Predicted to colocalize with voltage-gated Potassium Channel complex. [provided by Alliance of Genome Resources, Apr 2022]

AMIGO1 Products(1)

mRNA Protein Name
NM_020703.4 NP_065754.2 amphoterin-induced protein 1 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AMIGO1 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (110 - 170)

LRR_1

LRR_1: Leucine Rich Repeat (186 - 208)

V-set

V-set: Immunoglobulin V-set domain (285 - 357)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
Protein Preferred Names Protein Names

amphoterin-induced protein 1

alivin-2

AMIGO1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
AMIGO1 Q86WK6 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
Intra
AMIGO1 Q86WK6 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Intra
AMIGO1 Q86WK6 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra
AMIGO1 Q86WK6 PLPP6 Homo sapiens Q8IY26
Validated Y2H
32296183
Intra
AMIGO1 Q86WK6 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
Intra
AMIGO1 Q86WK6 TNMD Homo sapiens Q9H2S6-2
Validated Y2H
32296183
Intra
AMIGO1 Q86WK6 PGAP2 Homo sapiens Q9UHJ9-5
Validated Y2H
32296183
Intra
AMIGO1 Q86WK6 SLC41A1 Homo sapiens Q8IVJ1
Validated Y2H
32296183
Intra
AMIGO1 Q86WK6 PROM2 Homo sapiens Q8N271
Validated Y2H
32296183
Intra
AMIGO1 Q86WK6 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra
AMIGO1 Q86WK6 FAM3C Homo sapiens Q92520
Validated Y2H
32296183
Intra
AMIGO1 Q86WK6 HHATL Homo sapiens Q9HCP6
Validated Y2H
32296183
Intra
AMIGO1 Q86WK6 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra
AMIGO1 Q86WK6 TMEM79 Homo sapiens Q9BSE2
Validated Y2H
32296183
Intra
AMIGO1 Q86WK6 SELENOK Homo sapiens Q9Y6D0
Validated Y2H
32296183
Intra
AMIGO1 Q86WK6 SLC38A1 Homo sapiens Q9H2H9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Tungiasis

Tunga Penetrans Infestation

Chigger Flea

S Penetrans

Sarcopsylla Penetrans

T Penetrans

Tunga Penetrans

Sand-Flea Infestation

Jiggers Infestation

Chigoe Infestation

Jigger Disease
Developmental And Epileptic Encephalopathy 26

DEE26

Epileptic Encephalopathy, Early Infantile, 26

Eiee26

Early Infantile Epileptic Encephalopathy 26

Developmental And Epileptic Encephalopathy, 26

Encephalopathy, Epileptic, Early Infantile, Type 26
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00657 AMIGO1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus AMIGO1 MGD MGI:2653612
Felis catus AMIGO1 VGNC VGNC:59765
Rattus norvegicus AMIGO1 RGD RGD:1303079
Bos taurus AMIGO1 VGNC VGNC:25865
Canis familiaris AMIGO1 VGNC VGNC:37831
Macaca mulatta AMIGO1 VGNC VGNC:69653