1. Gene
  2. SLC7A6 - solute carrier family 7 member 6 Gene

SLC7A6 - solute carrier family 7 member 6 Gene

Homo sapiens

Also known as LAT3; LAT-2; y+LAT-2

Gene ID: 9057 | Gene type: protein coding

About SLC7A6

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:68,264,526-68,301,819 (from NCBI)

This gene has 17 transcripts (splice variants), 232 orthologues and 12 paralogues. Ubiquitous expression in fat (RPKM 11.5), lymph node (RPKM 10.0) and 24 other tissues.

Summary

Enables basic amino acid transmembrane transporter activity. Involved in basic amino acid transmembrane transport and ornithine transport. Located in intracellular membrane-bounded organelle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC7A6 Products(2)

mRNA Protein Name
NM_001076785.3 NP_001070253.1 Y+L amino acid transporter 2
NM_003983.6 NP_003974.3 Y+L amino acid transporter 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables L-arginine transmembrane transporter activity IDA
IDA: Inferred from direct assay
11311135 GOA
enables L-lysine:L-arginine antiporter activity IDA
IDA: Inferred from direct assay
10903140 GOA
enables arginine binding IDA
IDA: Inferred from direct assay
19562367 GOA
enables basic amino acid transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
17197568 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in L-arginine transmembrane transport IDA
IDA: Inferred from direct assay
10903140 GOA
involved in L-arginine transmembrane transport IMP
IMP: Inferred from mutant phenotype
31705628 GOA
involved in L-leucine transport IDA
IDA: Inferred from direct assay
16785209 GOA
involved in neutral amino acid transport IDA
IDA: Inferred from direct assay
10903140 GOA
involved in ornithine transport IMP
IMP: Inferred from mutant phenotype
17197568 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC7A6 Protein Structure

AA_permease_2

AA_permease_2: Amino acid permease (45 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 515 a.a.
Protein Preferred Names Protein Names

Y+L amino acid transporter 2

amino acid permease

SLC7A6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SLC7A6 Q92536 DOLK Homo sapiens Q9UPQ8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lysinuric Protein Intolerance

LPI

Dibasic Amino Aciduria Ii

Hyperdibasic Aminoaciduria

Dibasic Aminoaciduria 2

Dibasicamino Aciduria Ii

Congenital Lysinuria

Lpi - Lysinuric Protein Intolerance

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Cystinuria

CSNU

Cystinuria Type B

Cystinuria Type A

Cystinuria, Type I, Formerly

Csnu1, Formerly

Cystinuria, Type Ii, Formerly

Cystinuria, Type Iii, Formerly

Csnu3, Formerly

Cystinuria, Type Non-I, Formerly

Cystinuria-Lysinuria

Cystinuria-Lysinuria Syndrome

Csnu1

Csnu3

Cystinuria 1

Cystinuria Type A/B

Cystinuria Type I

Cystinuria Type Ii

Cystinuria Type Iii

Cystinuria Type Non-I

Cystinuria, Type A/B

Cystinuria Type 1

Cystinuria - Lysinuria

Csnu - [Cystinuria]

Cystine Disease

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus SLC7A6 VGNC VGNC:34931
Canis familiaris SLC7A6 VGNC VGNC:46476
Mus musculus SLC7A6 MGD MGI:2142598
Rattus norvegicus SLC7A6 RGD RGD:1309193
Macaca mulatta SLC7A6 VGNC VGNC:104751
Felis catus SLC7A6 VGNC VGNC:65427