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  3. SLC13A2 - solute carrier family 13 member 2 Gene

SLC13A2 - solute carrier family 13 member 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NaCT; NADC1; SDCT1; NaDC-1

Gene ID: 9058 | Gene type: protein coding

About SLC13A2

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,473,644-28,497,781 (from NCBI)

This gene has 6 transcripts (splice variants), 254 orthologues and 5 paralogues. Biased expression in duodenum (RPKM 49.7), small intestine (RPKM 41.0) and 4 other tissues.

Summary

The protein encoded by this gene is a sodium-coupled citrate transporter that is regulated by the chaperone activity of Cyclophilin B. The encoded protein may play a role in the formation of kidney stones. [provided by RefSeq, Oct 2016]

SLC13A2 Products(4)

mRNA Protein Name
NM_001145975.2 NP_001139447.1 solute carrier family 13 member 2 isoform a
NM_001346683.2 NP_001333612.1 solute carrier family 13 member 2 isoform d
NM_001346684.2 NP_001333613.1 solute carrier family 13 member 2 isoform e
NM_003984.4 NP_003975.1 solute carrier family 13 member 2 isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables alpha-ketoglutarate transmembrane transporter activity IDA
IDA: Inferred from direct assay
10894787 GOA
enables fumarate transmembrane transporter activity IDA
IDA: Inferred from direct assay
10894787 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sodium:dicarboxylate symporter activity IDA
IDA: Inferred from direct assay
10894787 GOA
enables succinate transmembrane transporter activity IDA
IDA: Inferred from direct assay
10894787 GOA
Biological Process GO Annotation Evidence Reference Source
involved in alpha-ketoglutarate transport IDA
IDA: Inferred from direct assay
10894787 GOA
involved in cellular response to lithium ion IDA
IDA: Inferred from direct assay
10894787 GOA
involved in fumarate transport IDA
IDA: Inferred from direct assay
10894787 GOA
involved in succinate transmembrane transport IDA
IDA: Inferred from direct assay
10894787 GOA
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
27927654 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC13A2 Protein Structure

Na_sulph_symp

Na_sulph_symp: Sodium:sulfate symporter transmembrane region (6 - 565)

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  • 592 a.a.
Protein Preferred Names Protein Names

solute carrier family 13 member 2

Na(+)-coupled citrate transporter

SLC13A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SLC13A2 Q13183 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
SLC13A2 Q13183 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
SLC13A2 Q13183 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
SLC13A2 Q13183 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
SLC13A2 Q13183 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
SLC13A2 Q13183 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
SLC13A2 Q13183 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
SLC13A2 Q13183 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nephrolithiasis, Uric Acid

Nephrolithiasis, Uric Acid, Susceptibility To

Uric Acid Urolithiasis

Uric Acid Nephrolithiasis

UAN

Acute Urate Nephropathy

Urolithiasis, Uric Acid

Urolithiasis, Uric Acid, Susceptibility To

Uric Acid Renal Calculus
Developmental And Epileptic Encephalopathy 25

Developmental And Epileptic Encephalopathy, 25

Dee25

Developmental And Epileptic Encephalopathy 25, With Amelogenesis Imperfecta

Early Infantile Epileptic Encephalopathy 25

Encephalopathy, Epileptic, Early Infantile, Type 25
Nephrolithiasis

Kidney Stones

Stone - Kidney/Ureter

Kidney Calculi
Hyperoxaluria, Primary, Type Ii

Primary Hyperoxaluria Type 2

D-Glycerate Dehydrogenase Deficiency

Glyoxylate Reductase/Hydroxypyruvate Reductase Deficiency

HP2

Oxalosis Ii

Glyceric Aciduria

L-Glyceric Aciduria

Primary Hyperoxaluria, Type Ii

Oxalosis 2

Hyperoxaluria Primary 2

Hyperoxaluria Primary Type Ii

Ph2

Primary Hyperoxaluria Type Ii
Sialolithiasis

Sialolith

Stone Of Salivary Gland Or Duct

Salivary Gland Calculi

Salivary Gland Stone

Calculus Of Salivary Gland Or Duct

Calculus Of Salivary Gland

Salivary Calculus

Salivary Gland Calculus

Salivary Stone

Salivary Duct Calculi

Sialodocholithiasis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13006 SLC13A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SLC13A2 VGNC VGNC:65197
Rattus norvegicus SLC13A2 RGD RGD:61920
Macaca mulatta SLC13A2 VGNC VGNC:99256
Canis familiaris SLC13A2 VGNC VGNC:46228
Bos taurus SLC13A2 VGNC VGNC:34674
Mus musculus SLC13A2 MGD MGI:1276558