SYT7 - synaptotagmin 7 Gene

Homo sapiens

Also known as IPCA7; IPCA-7; SYTVII; PCANAP7; SYT-VII

Gene ID: 9066 | Gene type: protein coding

About SYT7

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,513,714-61,588,387 (from NCBI)

This gene has 10 transcripts (splice variants), 266 orthologues and 31 paralogues. Biased expression in brain (RPKM 15.4), prostate (RPKM 13.8) and 12 other tissues.

Summary

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate Cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

SYT7 Products(7)

mRNA	Protein	Name
NM_001252065.2	NP_001238994.1	synaptotagmin-7 isoform 1
NM_001300773.2	NP_001287702.1	synaptotagmin-7 isoform 3
NM_001365809.2	NP_001352738.1	synaptotagmin-7 isoform 4
NM_001370210.1	NP_001357139.1	synaptotagmin-7 isoform 5
NM_001370211.1	NP_001357140.1	synaptotagmin-7 isoform 6
NM_001411007.1	NP_001397936.1	synaptotagmin-7 isoform 7
NM_004200.4	NP_004191.2	synaptotagmin-7 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYT7 Protein Structure

0
100
200
300
403 a.a.

Protein Preferred Names

Protein Names

synaptotagmin-7

prostate cancer-associated protein 7

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Mucolipidosis

Peroxisome Biogenesis Disorder 1b

Peroxisome Biogenesis Disorder	Infantile Refsum Disease
Infantile Phytanic Acid Storage Disease	PBD1B
Refsum Disease, Infantile	Adrenoleukodystrophy, Autosomal Neonatal
Ird	Mild Pbd-Zsd
Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder	Pbd-Zsd
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Autosomal Neonatal Adrenoleukodystrophy	Refsum Disease Infantile
Peroxisome Biogenesis Disorders	Peroxisome Biogenesis Disorder, Type 1b

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14119	SYT7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SYT7	VGNC	VGNC:65902
Mus musculus	SYT7	MGD	MGI:1859545
Bos taurus	SYT7	VGNC	VGNC:56283
Rattus norvegicus	SYT7	RGD	RGD:62013
Macaca mulatta	SYT7	VGNC	VGNC:101406
Canis familiaris	SYT7	VGNC	VGNC:47050

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