2. Gene
  3. CLDN10 - claudin 10 Gene

CLDN10 - claudin 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OSPL; HELIX; OSP-L; CPETRL3

Gene ID: 9071 | Gene type: protein coding

About CLDN10

Cytogenetic location: 13q32.1 Genomic coordinates (GRCh38): 13:95,433,755-95,579,759 (from NCBI)

This gene has 3 transcripts (splice variants), 419 orthologues, 22 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 32.5), salivary gland (RPKM 18.3) and 4 other tissues.

Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010]

CLDN10 Products(3)

mRNA Protein Name
NM_001160100.2 NP_001153572.1 claudin-10 isoform a_i1
NM_006984.5 NP_008915.1 claudin-10 isoform b precursor
NM_182848.4 NP_878268.1 claudin-10 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IDA
IDA: Inferred from direct assay
28028216 GOA
enables paracellular tight junction channel activity IDA
IDA: Inferred from direct assay
19383724 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in paracellular transport IDA
IDA: Inferred from direct assay
19383724 GOA
involved in regulation of monoatomic ion transport IMP
IMP: Inferred from mutant phenotype
28686597 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
28771254 GOA
located in tight junction IDA
IDA: Inferred from direct assay
19383724 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN10 Protein Structure

PMP22_Claudin

PMP22_Claudin: PMP-22/EMP/MP20/Claudin family (6 - 179)

  • 0
  • 100
  • 200
  • 228 a.a.
Protein Preferred Names Protein Names

claudin-10

OSP-like protein

CLDN10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CLDN10 P78369 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
CLDN10 P78369 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra
CLDN10 P78369 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
CLDN10 P78369 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Intra
CLDN10 P78369 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra
CLDN10 P78369 REEP1 Homo sapiens Q9H902
Y2H Prey Pooling
32296183
Intra
CLDN10 P78369 REEP1 Homo sapiens Q9H902
Y2H Array
32296183
Intra
CLDN10 P78369 REEP1 Homo sapiens Q9H902
Validated Y2H
32296183
Intra
CLDN10 P78369 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
CLDN10 P78369 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra
CLDN10 P78369 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
CLDN10 P78369 BEST2 Homo sapiens Q8NFU1
Validated Y2H
32296183
Intra
CLDN10 P78369 BEST2 Homo sapiens Q8NFU1
Y2H Array
32296183
Intra
CLDN10 P78369 BEST2 Homo sapiens Q8NFU1
Y2H Prey Pooling
32296183
Intra
CLDN10 P78369 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra
CLDN10 P78369 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra
CLDN10 P78369 TMEM9 Homo sapiens Q9P0T7
Validated Y2H
32296183
Intra
CLDN10 P78369 TMEM9 Homo sapiens Q9P0T7
Y2H Array
32296183
Intra
CLDN10 P78369 TMEM9 Homo sapiens Q9P0T7
Y2H Prey Pooling
32296183
Intra
CLDN10 P78369 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
CLDN10 P78369 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
CLDN10 P78369 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Helix Syndrome

HELIX

Hypohidrosis, Electrolyte Imbalance, Lacrimal Gland Dysfunction, Ichthyosis, And Xerostomia

Hypohidrosis-Electrolyte Imbalance-Lacrimal Gland Dysfunction-Ichthyosis-Xerostomia Syndrome
Anhidrosis

Hypohidrosis

Absence Of Sweating

Adiaphoresis

Impaired Sweating

Oligohidrosis
Adenocarcinoma In Situ
Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium

Adenosquamous Carcinoma Of The Endometrium

Endometrial Adenosquamous Cancer

Endometrial Adenosquamous Cell Carcinoma
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Ichthyosis

Ichthyoses

Non-Syndromic Ichthyosis

Congenital Ichthyosis
Deafness, Autosomal Recessive 29

DFNB29

Autosomal Recessive Nonsyndromic Deafness 29

Autosomal Recessive Deafness 29

Deafness, Autosomal Recessive, 29

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 29

Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 29

Deafness, Autosomal Recessive, Type 29
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02763 CLDN10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CLDN10 VGNC VGNC:39309
Bos taurus CLDN10 VGNC VGNC:27403
Macaca mulatta CLDN10 VGNC VGNC:71243
Rattus norvegicus CLDN10 RGD RGD:1308027
Mus musculus CLDN10 MGD MGI:1913101
Felis catus CLDN10 VGNC VGNC:102180