CISD2 - CDGSH iron sulfur domain 2 Gene

Homo sapiens

Also known as ERIS; WFS2; ZCD2; NAF-1; Miner1

Gene ID: 493856 | Gene type: protein coding

About CISD2

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:102,868,992-102,892,807 (from NCBI)

This gene has 5 transcripts (splice variants), 215 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 8.6), kidney (RPKM 5.5) and 25 other tissues.

Summary

The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]

CISD2 Products(1)

mRNA	Protein	Name
NM_001008388.5	NP_001008389.1	CDGSH iron-sulfur domain-containing protein 2

CISD2 Protein Structure

MitoNEET_N

zf-CDGSH

0
100
135 a.a.

Protein Preferred Names

Protein Names

CDGSH iron-sulfur domain-containing protein 2

endoplasmic reticulum intermembrane small protein

CISD2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CISD2	Q8N5K1	SLC35B4	Homo sapiens	Q969S0	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	PNKP	Homo sapiens	Q96T60	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	CFHR5	Homo sapiens	Q9BXR6	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	C4orf3	Homo sapiens	Q8WVX3-2	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	NRAC	Homo sapiens	Q8N912	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	PGAP2	Homo sapiens	Q9UHJ9-5	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	FAM241B	Homo sapiens	Q96D05-2	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	MAN2B2	Homo sapiens	Q9Y2E5	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	AQP10	Homo sapiens	Q96PS8	Y2H Array	32296183
Intra	CISD2	Q8N5K1	AQP10	Homo sapiens	Q96PS8	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	TMEM243	Homo sapiens	Q9BU79	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	SLC13A3	Homo sapiens	Q8WWT9	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	PLPPR2	Homo sapiens	Q96GM1	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	POMGNT1	Homo sapiens	Q8WZA1	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	NAPB	Homo sapiens	Q9H115	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	APOL2	Homo sapiens	Q9BQE5	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	HHATL	Homo sapiens	Q9HCP6	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	CLN6	Homo sapiens	Q9NWW5	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	BCL2L2	Homo sapiens	Q92843	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	TMEM43	Homo sapiens	Q9BTV4	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	SERP2	Homo sapiens	Q8N6R1	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	BCL2	Homo sapiens	P10415	Anti Bait CoIP	20010695
Intra	CISD2	Q8N5K1	BCL2	Homo sapiens	P10415	Pull Down	20010695
Intra	CISD2	Q8N5K1	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	NRG4	Homo sapiens	Q8WWG1	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	BTN2A2	Homo sapiens	Q8WVV5	Validated Y2H	32296183
Intra	CISD2	Q8N5K1	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Wolfram Syndrome 2

WFS2

Wolfram Syndrome

Didmoad Syndrome	Didmoad
Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness	Wfs
Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness	Didmoadud
Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome	Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome

Wolfram Syndrome 1

WFS1	Didmoad
Wfs	Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness
Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness	Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome
Wolfram Syndrome

Diabetes Insipidus

Noonan Syndrome 13

NS13

Primary Optic Atrophy

3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy	3-Methylglutaconic Aciduria Type 3
Costeff Syndrome	Mga3
Costeff Optic Atrophy Syndrome	Optic Atrophy Plus Syndrome
Infantile Optic Atrophy With Chorea And Spastic Paraplegia	3-Methylglutaconic Aciduria Type Iii
Autosomal Recessive Optic Atrophy Plus Syndrome	Autosomal Recessive Optic Atrophy Type 3
Opa3 Defect	MGCA3
Mga, Type Iii	Iraqi Jewish Optic Atrophy Plus
Mga Type Iii	Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia
Iraqi-Jewish 'Optic Atrophy Plus'	Optic Atrophy 3, Autosomal Recessive
Opa3, Autosomal Recessive	Opa3-Related 3-Methylglutaconic Aciduria
Iraqi-Jewish Optic Atrophy Plus	Atrophy Of Optic Disc
3-Alpha Methylglutaconic Aciduria Type Iii	Optic Atrophy 3
Optic Atrophy Infantile With Chorea And Spastic Paraplegia	Autosomal Recessive Opa3
Autosomal Recessive Optic Atrophy 3	3-Methylglutaconic Aciduria 3
3-Alpha-Methylglutaconic Aciduria Type 3	Optic Atrophy 3 Autosomal Recessive
Atrophy, Optic	Atrophy, Optic, Plus Syndrome
Optic Nerve Atrophy	Primary Optic Atrophy
Oa - [Optic Atrophy]	Second Cranial Nerve Atrophy
Second Cranium Nerve Atrophy

Waardenburg Syndrome, Type 1

Waardenburg Syndrome Type 1	WS1
Waardenburg Syndrome Type I	Waardenburg Syndrome With Dystopia Canthorum
Waardenburg'S Syndrome Type 1	Waardenburg Syndrome 1
Waardenburg Syndrome, Type I	Waardenburg Syndrome

Neurogenic Bladder

Neurogenic Dysfunction Of The Urinary Bladder	Neurogenic Urinary Bladder Disorder
Neuropathic Bladder	Bladder Neurogenic
Urinary Bladder, Neurogenic	Neurogenic Urinary Bladder

Waardenburg'S Syndrome

Waardenburg Syndrome	Van Der Hoeve Halbertsma Waardenburg Gualdi Syndrome
Van Der Hoeve Halbertsona Waardenburg Syndrome	Waardenburg Shah Syndrome
Waardenburg, Types I And/Or Ii	Mende Syndrome
Waardenburgs Syndrome	Waardenburg Syndrome, Type 4a

Optic Nerve Disease

Optic Neuropathy	Disorder Of The Second Nerve
Optic Nerve Disorder	Optic Nerve
Abnormality Of The Optic Nerve	Optic Nerve Disorders
Neuropathy, Optic	Disorder Of The Optic Nerve

Cranial Nerve Disease

Cranial Nerve Disorder	Disorder Of Cranial Nerve
Cranial Nerve Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-155538	Cisd2 agonist 1	Agonist	99.22%	Unkown
HY-155539	Cisd2 agonist 2	Activator	99.17%	Unkown
HY-RS02724	CISD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CISD2	VGNC	VGNC:27372
Felis catus	CISD2	VGNC	VGNC:78470
Macaca mulatta	CISD2	VGNC	VGNC:106563
Rattus norvegicus	CISD2	RGD	RGD:1566242
Mus musculus	CISD2	MGD	MGI:1914256
Canis familiaris	CISD2	VGNC	VGNC:39279

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