MS4A3 - membrane spanning 4-domains A3 Gene

Homo sapiens

Also known as HTM4; CD20L

Gene ID: 932 | Gene type: protein coding

About MS4A3

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:60,056,665-60,071,115 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 93 orthologues and 16 paralogues. Restricted expression toward bone marrow (RPKM 168.2).

Summary

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

MS4A3 Products(3)

mRNA	Protein	Name
NM_001031666.2	NP_001026836.1	membrane-spanning 4-domains subfamily A member 3 isoform c
NM_001031809.2	NP_001026979.1	membrane-spanning 4-domains subfamily A member 3 isoform b
NM_006138.5	NP_006129.4	membrane-spanning 4-domains subfamily A member 3 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15671017	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MS4A3 Protein Structure

CD20

0
100
200
214 a.a.

Protein Preferred Names

Protein Names

membrane-spanning 4-domains subfamily A member 3

CD20 antigen homolog

MS4A3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MS4A3	Q96HJ5	TEX264	Homo sapiens	Q9Y6I9	Complementation	32296183
Intra	MS4A3	Q96HJ5	TEX264	Homo sapiens	Q9Y6I9	Validated Y2H	32296183
Intra	MS4A3	Q96HJ5	SLC5A4	Homo sapiens	Q9NY91	Validated Y2H	32296183
Intra	MS4A3	Q96HJ5	SLC22A14	Homo sapiens	Q9Y267	Validated Y2H	32296183
Intra	MS4A3	Q96HJ5	SLC22A14	Homo sapiens	Q9Y267	Complementation	32296183
Intra	MS4A3	Q96HJ5	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	MS4A3	Q96HJ5	ATP6V0B	Homo sapiens	Q99437	Validated Y2H	32296183
Intra	MS4A3	Q96HJ5	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	MS4A3	Q96HJ5	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	MS4A3	Q96HJ5	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	32296183
Intra	MS4A3	Q96HJ5	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	MS4A3	Q96HJ5	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183
Intra	MS4A3	Q96HJ5	CCDC167	Homo sapiens	Q9P0B6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Dominant 22

MRD22	Mental Retardation, Autosomal Dominant 22
Autosomal Dominant Non-Syndromic Intellectual Disability 22	Distal Monosomy 1q
Autosomal Dominant Intellectual Developmental Disorder 22	Autosomal Dominant Mental Retardation 22
Distal Deletion 1q	Monosomy 1qter
Telomeric Deletion 1q	Mental Retardation, Autosomal Dominant, Type 22

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08701	MS4A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MS4A3	RGD	RGD:1310598
Mus musculus	MS4A3	MGD	MGI:2158468
Bos taurus	MS4A3	VGNC	VGNC:58392

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