ZNF598 - zinc finger protein 598, E3 ubiquitin ligase Gene

Homo sapiens

Also known as HEL2

Gene ID: 90850 | Gene type: protein coding

About ZNF598

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,997,654-2,009,821 (from NCBI)

This gene has 9 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in testis (RPKM 7.9), spleen (RPKM 7.8) and 25 other tissues.

Summary

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and Apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. [provided by RefSeq, Oct 2012]

ZNF598 Products(3)

mRNA	Protein	Name
NM_001405664.1	NP_001392593.1	E3 ubiquitin-protein ligase ZNF598 isoform 2
NM_001405665.1	NP_001392594.1	E3 ubiquitin-protein ligase ZNF598 isoform 3
NM_178167.5	NP_835461.2	E3 ubiquitin-protein ligase ZNF598 isoform 1

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase ZNF598

ZNF598 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF598	Q86UK7	YWHAE	Homo sapiens	P62258	Crosslink	36931259

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16157	ZNF598 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZNF598	RGD	RGD:1304900
Canis familiaris	ZNF598	VGNC	VGNC:48771
Macaca mulatta	ZNF598	VGNC	VGNC:99638
Mus musculus	ZNF598	MGD	MGI:2670965
Felis catus	ZNF598	VGNC	VGNC:67332
Bos taurus	ZNF598	VGNC	VGNC:37309

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