SPSB3 - splA/ryanodine receptor domain and SOCS box containing 3 Gene

Homo sapiens

Also known as SSB3; C16orf31

Gene ID: 90864 | Gene type: protein coding

About SPSB3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,776,712-1,782,571 (from NCBI)

This gene has 12 transcripts (splice variants), 254 orthologues and 4 paralogues. Ubiquitous expression in skin (RPKM 23.4), spleen (RPKM 22.6) and 25 other tissues.

Summary

Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of SCF ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

SPSB3 Products(2)

mRNA	Protein	Name
NM_001324081.1	NP_001311010.1	SPRY domain-containing SOCS box protein 3
NM_080861.4	NP_543137.2	SPRY domain-containing SOCS box protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	29059170	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	38418882	GOA
involved in negative regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	29059170	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	29059170	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	38418882	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul5-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	29059170	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	38418882	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPSB3 Protein Structure

SPRY

0
100
200
300
355 a.a.

Protein Preferred Names

Protein Names

SPRY domain-containing SOCS box protein 3

SPRY domain-containing SOCS box protein SSB-3

Related Diseases

Diseases

Alias

Hypochondriasis

Hypochondriacal Disorder	Hypochondria
Hypochondriacal Neurosis	Illness Anxiety Disorder
Health Anxiety Disorder	Hypochondriacal Reaction

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13728	SPSB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SPSB3	MGD	MGI:1891471
Rattus norvegicus	SPSB3	RGD	RGD:1310936
Macaca mulatta	SPSB3	VGNC	VGNC:78025
Bos taurus	SPSB3	VGNC	VGNC:35248
Felis catus	SPSB3	VGNC	VGNC:65656
Canis familiaris	SPSB3	VGNC	VGNC:46771

Name
Email *

	Sorry, but the email address you supplied was invalid.