NUMBL - NUMB like endocytic adaptor protein Gene

Homo sapiens

Also known as NBL; CAG3A; CTG3a; NUMBR; NUMB-R; TNRC23; NUMBLIKE

Gene ID: 9253 | Gene type: protein coding

About NUMBL

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,665,905-40,690,651 (from NCBI)

This gene has 11 transcripts (splice variants), 200 orthologues and 11 paralogues. Ubiquitous expression in brain (RPKM 8.6), endometrium (RPKM 7.2) and 25 other tissues.

Summary

Involved in cytokine-mediated signaling pathway and protein metabolic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NUMBL Products(3)

mRNA	Protein	Name
NM_001289979.2	NP_001276908.1	numb-like protein isoform b
NM_001289980.2	NP_001276909.1	numb-like protein isoform b
NM_004756.5	NP_004747.1	numb-like protein isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16273093	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	18299187	GOA
involved in protein metabolic process	IDA IDA: Inferred from direct assay	20079715	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUMBL Protein Structure

PID

NumbF

0
100
200
300
400
500
609 a.a.

Protein Preferred Names

Protein Names

numb-like protein

numb homolog-like

NUMBL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUMBL	Q9Y6R0	CDK5	Homo sapiens	Q00535	Y2H Pooling	32814053
Intra	NUMBL	Q9Y6R0	CDK5	Homo sapiens	Q00535	Validated Y2H	32814053
Intra	NUMBL	Q9Y6R0	CDK5	Homo sapiens	Q00535	Y2H Array	32814053
Intra	NUMBL	Q9Y6R0	CLSTN1	Homo sapiens	O94985-2	Y2H Pooling	32814053
Intra	NUMBL	Q9Y6R0	CLSTN1	Homo sapiens	O94985-2	Validated Y2H	32814053
Intra	NUMBL	Q9Y6R0	CLSTN1	Homo sapiens	O94985-2	Y2H Array	32814053
Intra	NUMBL	Q9Y6R0	EGFR	Homo sapiens	P00533	Protein Array	16273093
Intra	NUMBL	Q9Y6R0	RBFOX1	Homo sapiens	Q9NWB1	Y2H Array	16713569

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Differentiating Neuroblastoma

Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia	XLN
SCNX	Severe Congenital Neutropenia X-Linked
Neutropenia, Congenital, Severe, X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09682	NUMBL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NUMBL	VGNC	VGNC:32349
Macaca mulatta	NUMBL	VGNC	VGNC:75558
Rattus norvegicus	NUMBL	RGD	RGD:1307579
Canis familiaris	NUMBL	VGNC	VGNC:44043
Mus musculus	NUMBL	MGD	MGI:894702
Felis catus	NUMBL	VGNC	VGNC:68597

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