RRP9 - ribosomal RNA processing 9, U3 small nucleolar RNA binding protein Gene

Homo sapiens

Also known as U3-55K; RNU3IP2

Gene ID: 9136 | Gene type: protein coding

About RRP9

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,933,429-51,941,904 (from NCBI)

This gene has 1 transcript (splice variant) and 205 orthologues. Ubiquitous expression in appendix (RPKM 6.7), adrenal (RPKM 6.6) and 25 other tissues.

Summary

This gene encodes a member of the WD-repeat protein family. The encoded protein is a component of the nucleolar small nuclear ribonucleoprotein particle (snoRNP) and is essential for 18s rRNA processing during ribosome synthesis. It contains seven WD domains required for nucleolar localization and specific interaction with the U3 small nucleolar RNA (U3 snoRNA). [provided by RefSeq, Oct 2012]

RRP9 Products(1)

mRNA	Protein	Name
NM_004704.5	NP_004695.1	U3 small nucleolar RNA-interacting protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to U3 snoRNA binding	IDA IDA: Inferred from direct assay	9418896	GOA
enables U3 snoRNA binding	IDA IDA: Inferred from direct assay	26867678	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26867678	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in rRNA processing	IDA IDA: Inferred from direct assay	26867678	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of box C/D methylation guide snoRNP complex	IDA IDA: Inferred from direct assay	9418896	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	9418896	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRP9 Protein Structure

WD40

0
100
200
300
400
475 a.a.

Protein Preferred Names

Protein Names

U3 small nucleolar RNA-interacting protein 2

RNA, U3 small nucleolar interacting protein 2

RRP9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RRP9	O43818	NOP56	Homo sapiens	O00567	Anti Tag CoIP	33961781
Intra	RRP9	O43818	NOP56	Homo sapiens	O00567	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12293	RRP9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RRP9	VGNC	VGNC:77028
Felis catus	RRP9	VGNC	VGNC:64783
Bos taurus	RRP9	VGNC	VGNC:34172
Canis familiaris	RRP9	VGNC	VGNC:45767
Mus musculus	RRP9	MGD	MGI:2384313
Rattus norvegicus	RRP9	RGD	RGD:1307881

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